For a linear regression design matrix with full column rank, the ordinary least squares coefficient vector is . In a normal linear model with error covariance matrix , it is an unbiased estimator with covariance matrix . Replacing by the residual variance estimate gives the reported coefficient standard errors.
In simple linear regression with a nonconstant predictor,
For a nonconstant predictor, put
The minimized residual sum of squares is
Each centered sum can be recovered in constant time from the five raw sums , , , , and .

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