Past exam of the further mathematical biology course of the University of Oxford / 2023 / 2 / a / i / Solution

Put $k=\beta /\gamma$. The nullclines of the space-clamped FitzHugh-Nagumo model areThe first nullcline is a downward-leading cubic polynomial, shifted vertically by $I$; the second nullcline is a line through the origin with slope $k>0$. Their intersections satisfyWriting $M=(1-\alpha +{\alpha }^2)/3$, differentiation givesIf $k>M$, $h$ increases strictly, so there is exactly one equilibrium. If $k=M$, $h$ is still strictly increasing, although its derivative vanishes at one point, so the equilibrium is again unique. If $0<k<M$, defineHere $h$ has a local maximum at $u_{-}$ and a local minimum at $u_{+}$; thereforeAt either endpoint there are two distinct equilibria, one a double root. These are the saddle-node bifurcation boundaries omitted by the generic one-or-three wording. At $k=M$ and $I=h((1+\alpha )/3)$ there is one triple root. This is the Cubic FitzHugh-Nagumo nullcline criterion.