A useful convention for the semi-empirical mass formula is
where is the binding energy. The nuclear mass is . Atomic-mass comparisons instead use hydrogen-atom masses and account for electron binding at the desired accuracy. No numerical fit coefficients are specified here.
The volume term represents short-range nuclear attraction with saturation: each nucleon has a limited number of close neighbours. The surface term subtracts the binding lost by nucleons at the boundary. Coulomb repulsion penalizes a large proton fraction. The asymmetry term penalizes unequal neutron and proton populations, reflecting the cost of filling different Fermi seas and nuclear interactions. Pairing favours even-even nuclei and penalizes odd-odd nuclei; odd- nuclei have zero pairing term in this approximation. For example, one may choose ; an alternative fitted power requires a correspondingly different coefficient.
At fixed , the smooth mass dependence on is approximately parabolic. Neglecting the neutron-proton mass difference, pairing and small linear-in- Coulomb corrections, minimization gives
Thus the preferred neutron excess grows with mass number. The surface penalty disfavors very light systems, while the growing Coulomb penalty reduces the binding per nucleon of very heavy systems; this explains broad fusion and fission energy trends. The formula is a bulk approximation: shell closures, deformation and small separation-energy differences can give important exceptions. A fitted average binding trend is not a reliable substitute for a measured decay threshold near a boundary of stability.

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