For the independent statistical sample, write the likelihood function and log-likelihood function as
The expected Fisher information in the whole statistical sample is
Under the regularity conditions that permit differentiation under the integral sign, the score function has expected value zero and
For an interior statistical parameter, assuming identifiability and , the regular asymptotic normality of a maximum likelihood estimator states
Thus the large-sample normal approximation is . The inverse information is the leading sampling variance approximation; the displayed convergence specifies its precise asymptotic meaning.

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