A statistical parameter indexes a family of probability distributions in a statistical model. It is fixed in a frequentist sampling model; a prior distribution makes it random for Bayesian statistics. Different statistical parameter values should produce different observable distributions when identifiability is claimed.
A nuisance parameter is a statistical parameter required to specify the distribution of observations but not itself the target of inference. A profile likelihood maximizes over it; Bayesian model evidence integrates over it using a proper prior distribution. These operations differ and need not give the same inference. A baseline hazard in a Cox proportional-hazards model is an infinite-dimensional example.
On a common positive support, a factorization implies . Thus any nonzero mixed derivative prevents this exact separation. For independent gamma distributed observations with shape and rate , this mixed derivative is , so exact separation of shape and rate into such factors is impossible.
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