Past exam of the mathematics course of the University of Cambridge 2016 iii Paper 207 7 d Solution Created 2026-10-03 Updated 2026-10-06
Use the allowed ratio-of-expectations approximation where . The unconditional numerator and denominator from part (b) giveThe common censoring survivor function cancels in this approximation. By differentiating the logarithm, its value is the population integrated hazard:This is not generally the arithmetic mean of the ; it is the cumulative hazard function of the population mixture from part (a). The cancellation requires a common independent censoring law and adequate observation of the time range.
The approximation establishes approximate unbiasedness, not exact finite-sample unbiasedness. For a direct counterexample, take one uncensored individual with exponential distribution of rate . The Nelson–Aalen estimator is then , whose expectation is , whereas . Thus it is not an unbiased estimator in general.
More explicitly, for independent individuals with a common event hazard , the exact expected estimator isThis exhibits finite-sample bias of Nelson–Aalen estimation and dependence on when empty risk sets are possible. In a heterogeneous population, replacing the random ratios by ratios of their means introduces an additional approximation. On adequately observed intervals with large risk sets, the population-mixture expression is the appropriate large-sample target.
Past exam of the mathematics course of the University of Cambridge 2017 iii Paper 207 4 b ii Solution Created 2026-10-03 Updated 2026-10-05
If the final individual experiences an event at , the Kaplan–Meier estimator acquires the factor . ThusThe conventional fitted curve is zero thereafter. Its area gives the finite plug-in estimateThe area is a sum of rectangles: if are the event times, it equals . Censoring times within a constant segment do not alter its area.
Both terminal estimates have poor reliability because the last risk set has size one: one observed outcome determines whether the entire remaining fitted tail stays positive or collapses to zero. The zero tail is an empirical endpoint convention, not evidence that every future member of the population must fail by . With earlier right censoring, the displayed finite area can be especially sensitive to this last event and does not remove uncertainty about the population tail. In the final-censoring case the full mean lacks a determined tail area; in the final-event case the conventional full fitted mean is finite and calculable, but should be reported with this limitation. A restricted mean survival time at a prespecified cutoff within reliable follow-up often avoids the unstable terminal extrapolation.
Past exam of the mathematics course of the University of Cambridge 2017 iii Paper 207 4 b i Solution Created 2026-10-03 Updated 2026-10-05
Let be the distinct observed event times, the risk set size immediately before , and the events there. Under independent censoring, the Kaplan–Meier estimator isIt starts at one, jumps down at events, and is unchanged by a pure censoring time; right censoring removes people from subsequent risk sets. If events and censorings coincide, the convention here processes events before censoring, so those censored at the recorded time are included just before the event. The estimated median is the first time the curve reaches or falls below . If it never does during observation, the median is not estimable from the observed curve without tail assumptions.
With one remaining individual censored at , no event factor is introduced. HenceThis is the terminal observed step value. With an empty risk set after , continued horizontal plotting is a convention and supplies no information about the true later survivor function. The tail rests on one person and is imprecise; this is terminal censoring and survival-mean identifiability. If , the unrestricted mean cannot be obtained nonparametrically from this censored tail: extending the last positive step to infinity would give an infinite area, which does not establish an infinite population mean. A restricted mean survival time up to a suitably supported finite cutoff remains estimable.
Past exam of the mathematics course of the University of Cambridge 2017 iii Paper 207 5 a Solution Created 2026-10-03 Updated 2026-10-05
A proportional hazards model assigns individual the hazard function , where is the baseline hazard for multiplier one and is a time-constant hazard multiplier. In a Cox proportional-hazards model, for a covariate vector and coefficient vector ; ratios are constant whenever the baseline is nonzero.
Assume independent individuals, independent censoring conditional on the covariates, and no tied events. Immediately before an event at , condition on its observed risk set and one event in a small time interval. The individual event probability is , while the total is . Their limiting ratio is . Multiplication over observed events gives the Cox partial likelihoodThe unspecified baseline hazard cancels. This is the usual successive conditional event contribution defining the partial likelihood, not the full event-time likelihood conditioned simultaneously on all event times.
For the four individuals the successive event risk sets are , and . Individual leaves at its right censoring time and contributes no event numerator. ConsequentlyThe last event contributes one and carries no further relative-risk information.
Past exam of the mathematics course of the University of Cambridge 2017 iii Paper 207 5 c Solution Created 2026-10-03 Updated 2026-10-05
The ordinary Nelson–Aalen estimator adds at event time . Under a fitted proportional hazards model, replace the number at risk by the sum of fitted hazard multipliers:This is the Breslow estimator of the integrated baseline hazard, using fitted regression coefficients obtained by maximizing the Cox partial likelihood. The denominator arises because the total event intensity is ; with every multiplier equal to one it reduces to the Nelson–Aalen estimator.
The estimator is right-continuous, so already includes the event at . Subtracting it leaves only the events at and , whose risk sets are and . HenceThere is no increment at the censoring time . If the lower endpoint had instead been , an additional would be present. The final singleton event can increase the baseline hazard estimate even though its partial likelihood contribution is one.
Past exam of the mathematics course of the University of Cambridge 2017 iii Paper 207 7 a Solution Created 2026-10-03 Updated 2026-10-05
A frailty model represents unobserved heterogeneity using a nonnegative frailty random variable that multiplies an individual's baseline hazard. With , the individual and population survivor functions areThus the population survivor function is the Laplace transform of the frailty distribution at ; at points where differentiation is justified, . The last identity follows by differentiating the integral and dividing by .
Here for , , and . Direct integration givesThis is population hazard under exponential frailty. For every fixed the individual hazard function increases linearly. In contrast,so the population hazard increases up to , then decreases, tending to zero like . More vulnerable individuals leave the risk set earlier, leaving survivors with smaller frailties. This population decline is selection, not a decline in any fixed individual's hazard. If , survival is identically one and both hazards vanish; the positive-rate comparison is then inapplicable.
Past exam of the mathematics course of the University of Cambridge 2018 iii Paper 207 4 b iii Solution Created 2026-10-03 Updated 2026-10-05
The estimate remains . Individuals right-censored at are observed throughout the preceding interval, so they contribute to each risk set until the end. They must not be removed from the denominator at .
If events and right censoring share the recorded time , use the usual Kaplan–Meier estimator convention: count events first, using a risk set that still includes those censored at that time, and then remove the censored observations. With no earlier censoring, the product of event factors over the interval telescopes to .
Past exam of the mathematics course of the University of Cambridge 2018 iii Paper 207 4 b ii Solution Created 2026-10-03 Updated 2026-10-05
An individual is right-censored at when follow-up establishes that the event has not occurred through , but does not reveal the subsequent event time. The observed information is for the continuous-time convention.
Knowing only the total number censored inside an interval does not specify the risk sets at the event times. For example, start with two individuals, one event and one censoring. If censoring precedes the event, the Kaplan–Meier estimator contributes ; if the event precedes censoring, it contributes . The totals are identical.
Therefore the timing of right censoring relative to the events is needed. Independent censoring is also required for these changing risk sets to yield a valid estimate of the underlying survivor function.
Past exam of the mathematics course of the University of Cambridge 2018 iii Paper 207 4 c iii Solution Created 2026-10-03 Updated 2026-10-05
Let be the number of events at potential time and let be the size of the risk set immediately before that time, including observations censored at . Define the discrete conditional event probabilityUnder independent censoring, and ignoring the separate censoring distribution, the survival likelihood factorizes asThis follows by multiplying a survival factor for each individual at risk who does not fail at , and an event factor for each failure. The log factor is maximized at , with the corresponding boundary values when or .
The survival function is the product of successive conditional survival probabilities. ThereforeThis is the Kaplan–Meier estimator. A product over no event times is 1. If everyone remaining experiences an event, the product becomes zero and stays zero; subsequent empty risk sets supply no additional factor.
Past exam of the mathematics course of the University of Cambridge 2018 iii Paper 207 4 c ii Solution Created 2026-10-03 Updated 2026-10-05
The set must contain every observed event time. Otherwise a discrete survival likelihood would assign probability zero to at least one exact event observation.
The set can include additional times without observed events. Include time zero when events at zero are present, and allow remaining tail probability beyond the fitted range. Estimation of a conditional event mass requires a nonempty risk set; once follow-up ends, later probability masses are not identified by the data. The usual Kaplan–Meier estimator retains the final estimated survival probability as its tail convention.
Past exam of the mathematics course of the University of Cambridge 2018 iii Paper 207 4 c iv Solution Created 2026-10-03 Updated 2026-10-05
At an added potential event time with no event and a nonempty risk set, , so maximum likelihood estimation gives . Its factor in the Kaplan–Meier estimator is therefore .
Adding or deleting such times also leaves the risk sets at actual event times unchanged: those depend on the observed event and censoring histories. Consequently the fitted survivor function depends only on observed event times and their risk sets. Beyond the last observed follow-up, the tail is not identified; the standard flat continuation is a convention, rather than an additional consequence of likelihood maximization.