The signal recognition particle is an RNA–protein targeting complex linking a ribosome-associated nascent chain to the SRP receptor.[ref]
Membrane Protein Insertion at the Endoplasmic Reticulum by Sichen Shao and Ramanujan S. Hegde. Shao and Hegde, 2011; “Cotranslational Targeting”, Figure 3
The bacterial homolog of the SRP54 protein, containing a GTPase involved in cotranslational membrane targeting.
Its signal-recognition and GTPase functions connect a nascent hydrophobic segment with the bacterial SRP receptor FtsY. The pathway directs selected translating ribosomes toward the membrane before the complete protein has been synthesized. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapters 3, 6 and 15, protein function, translation and cell signalling
The conserved eukaryotic SRP subunit containing a signal-sequence-binding region and a GTPase domain; bacterial Ffh is its homolog.
The SRP receptor receives the SRP–ribosome–nascent chain complex for handoff to the translocon.[ref]
Membrane Protein Insertion at the Endoplasmic Reticulum by Sichen Shao and Ramanujan S. Hegde. Shao and Hegde, 2011; “Cotranslational Targeting”, Figure 3
Reciprocal regulation of the receptor and SRP GTPases couples recognition to transfer of the nascent chain toward a membrane translocation site. This illustrates a targeting cycle in which simple binding is only one stage of productive delivery. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapters 3, 6 and 15, protein function, translation and cell signalling
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