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An unbiased estimator $T$ is uniformly minimum-variance unbiased if its variance is no larger than that of every other unbiased estimator of the same parameter, for every parameter value. The Lehmann–Scheffé theorem gives such an estimator whenever an unbiased function of a complete sufficient statistic exists. Attaining the Cramér-Rao bound is sufficient for this property under its hypotheses, but is not necessary: for $T\sim \Gamma (n,\lambda )$ with $n>2$, $(n-1)/T$ is unbiased and has variance ${\lambda }^2/(n-2)$, while the information bound is ${\lambda }^2/n$. Completeness follows from uniqueness of the Laplace transform of $h(t)t^{n-1}$, so the estimator is still uniformly optimal among unbiased estimators.

For a normal distribution $N_n(\mu ,{\sigma }^{2}I)$ with unrestricted $\mu \in {\mathbb{R}}^n$ and unknown ${\sigma }^2$, an integrable data-only unbiased estimator of the mean-vector prediction risk of a fixed rank-$k$ orthogonal projection matrix exists exactly when $2k=n$. To prove necessity, randomize the mean by independent Gaussian variance $v$: conditioning adds $(n-k)v$ to the squared bias term, whereas the marginal variance identity would add $kv$. When $2k=n$, the residual sum of squares itself is unbiased.

A U-statistic averages a symmetric function of $m$ distinct sample observations over all unordered $m$-tuples. For independent and identically distributed observations it is an unbiased estimator of $\mathbb{E}H(X_1,\dots ,X_m)$. Omitting repeated indices can remove diagonal contributions in quadratic plug-in estimators.