The Information Ratio (IR) is a financial metric used to measure the performance of an investment, such as a mutual fund or a portfolio, relative to a benchmark index, while taking into account the risk taken to achieve that performance. It provides insight into how much excess return (alpha) an investment generates for each unit of risk (tracking error) relative to the benchmark.
Potassium channels are a type of ion channel found in the membranes of cells, responsible for the selective passage of potassium ions (K+) across the membrane. They play critical roles in various physiological processes, including the regulation of cell membrane potential, the generation and propagation of action potentials in neurons and muscle cells, and the regulation of neurotransmitter release.
ASIC5 typically refers to a specific generation or version of Application-Specific Integrated Circuit (ASIC) technology. However, as of my last knowledge update in October 2023, there is no widely recognized concept or product specifically named "ASIC5" that stands out in major technological discussions or literature. ASICs are specialized hardware designed for a specific application, as opposed to general-purpose CPUs or GPUs.
CACNA2D2 (Calcium Voltage-Gated Channel Subunit Alpha2 Delta 2) is a gene that encodes a protein involved in the function of voltage-gated calcium channels in the body. These channels play a critical role in the regulation of calcium ion influx into cells, which is essential for various physiological processes, including muscle contraction, neurotransmitter release, and hormone secretion.
CLCNKB is a gene that encodes the Chloride Channel 2, which is part of the CLC (Chloride Channel) family of proteins. CLCNKB is primarily expressed in the kidney and plays a crucial role in regulating chloride ion transport in epithelial tissues. This gene is involved in kidney function, specifically in the reabsorption of chloride ions, which is essential for maintaining fluid and electrolyte balance in the body.
CLIC4, or Chloride Intracellular Channel 4, is a protein that is part of the CLIC (Chloride Intracellular Channel) family. It functions primarily as a chloride ion channel, playing a role in cellular processes such as ion transport, volume regulation, and cell signaling. CLIC4 is unique among its family members because it is also believed to have functions related to cell proliferation and differentiation, as well as involvement in various pathological conditions, including cancer.
Calcium channels are specialized proteins located in the cell membrane that facilitate the movement of calcium ions (Ca²⁺) into and out of cells. They play a crucial role in various physiological processes, including muscle contraction, neurotransmitter release, hormone secretion, and the regulation of heartbeat. There are several types of calcium channels, which can be broadly categorized into: 1. **Voltage-Gated Calcium Channels (VGCCs)**: These channels open in response to changes in membrane potential.
As of my last knowledge update in October 2021, "GABRE" does not refer to a widely recognized term or concept. However, it could represent various things depending on context, such as an acronym, a brand, a person's name, or even a project in a specific field.
CatSper1 (Cation Channel of Sperm 1) is a protein encoded by the CATSPER1 gene in humans and is a part of the CatSper (Cation Channel of Sperm) family. It is a vital component of the ion channels that are predominantly expressed in the sperm cells of mammals.
Cav1.2 is a type of voltage-gated calcium channel that is predominantly found in cardiac and smooth muscle, as well as in neurons. It is a member of the Cav1 family of calcium channels and is also known as the alpha-1C subunit of the channel. These channels are critical for the influx of calcium ions (Ca²⁺) into cells, which is essential for various physiological processes, including muscle contraction, neurotransmitter release, and gene expression.
Cyclic nucleotide-gated channel alpha 2 (CNG channel alpha 2) refers to a protein that is part of a group of ion channels known as cyclic nucleotide-gated (CNG) channels. These channels are primarily involved in sensory transduction processes, particularly in the olfactory system (for smell) and in photoreceptors in the retina (for vision).
Cyclic nucleotide-gated channel alpha 3 (CNGA3) is a protein that forms a part of the ion channel complex involved in sensory transduction, particularly in photoreceptors in the retina. It is one of the alpha subunits of the cyclic nucleotide-gated (CNG) channels, which are sensitive to cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP).
Cyclic nucleotide-gated (CNG) ion channels are a type of ion channel that are primarily activated by cyclic nucleotides, such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). These channels are critical components in various physiological processes, particularly in sensory transduction, including vision and olfaction.
F15845 does not correspond to a widely recognized product, term, or concept in my training data. It might be a specific identifier, a product code, a model number, or something relevant to a particular field. If you can provide more context or specify the category (e.g., technology, science, literature, etc.
GABRG3 is a gene that encodes a subunit of the gamma-aminobutyric acid (GABA) type A receptor, which is an important neurotransmitter receptor in the brain. This receptor is part of a large family of ligand-gated ion channels that mediate fast inhibitory synaptic transmission in the central nervous system.
GABRR1 (Gamma-aminobutyric acid receptor, rho 1) is a gene that encodes a protein belonging to the GABA receptor family. This family of receptors is responsible for mediating the effects of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the central nervous system. The GABRR1 protein is a type of GABA receptor that is primarily found in the brain.
ITPR1, or Inositol 1,4,5-trisphosphate receptor type 1, is a protein that in humans is encoded by the ITPR1 gene. It is part of a family of inositol trisphosphate receptors that play a critical role in cellular signaling.
ITPR3 stands for Inositol 1,4,5-trisphosphate receptor type 3. It is a protein encoded by the ITPR3 gene in humans. ITPR3 is part of the inositol trisphosphate receptor family, which plays a critical role in cellular signaling by regulating the release of calcium ions (Ca²⁺) from the endoplasmic reticulum (ER) into the cytoplasm.
Ion channels are specialized protein structures embedded in the cell membrane that facilitate the passage of ions (charged particles) in and out of cells. These channels are critical for various cellular functions, including the generation of electrical signals in nerve and muscle cells, the regulation of cellular volume, and the maintenance of ion concentrations across membranes.
KCNC2, or Potassium Voltage-Gated Channel Subfamily C Member 2, is a gene that encodes a protein which is part of the voltage-gated potassium channel family. These channels are crucial for the regulation of electrical excitability in various types of cells, including neurons and muscle cells. They play a key role in establishing the resting membrane potential and repolarizing the action potentials of excitable cells.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either https://OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact