Protein mimetics are synthetic compounds designed to imitate the structure or function of biological proteins. These compounds can mimic the properties of proteins in terms of their ability to interact with biological molecules, catalyze reactions, or perform various biological functions. Protein mimetics are used in various applications, including: 1. **Drug Development**: They can serve as potential therapeutic agents by mimicking the action of proteins involved in disease processes.
A reporter gene is a gene that researchers use to study the activity of other genes or regulatory sequences. It is typically a gene that encodes a protein producing an easily measurable signal, such as fluorescence or color change, which can be quantitated. Reporter genes are often used in molecular biology and genetics to monitor gene expression, track cellular processes, or evaluate the efficacy of different treatments.
SARM1, or SARM1 (Sterile Alpha and Toll/Interleukin-1 Receptor Motif Containing 1), is a protein that plays a crucial role in the process of neurodegeneration and neuronal injury, particularly in the context of peripheral nerve damage. It serves as a key mediator of axonal degeneration and is involved in signaling pathways that respond to axonal injury.
Subcloning is a molecular biology technique that involves the transfer of a specific DNA fragment (such as a gene, promoter, or regulatory element) from one plasmid or vector to another. This process is used to create a new DNA construct with desired features, often for research, genetic engineering, or therapeutic applications. Key steps in subcloning typically include: 1. **Restriction Digestion**: The original DNA fragment and the new vector are cut with specific restriction enzymes to create compatible ends.
Synthetic ion channels are artificially designed or constructed channels that mimic the function of natural ion channels found in cell membranes. These synthetic constructs are created using various techniques from fields such as chemistry, biology, and materials science. They are often designed to control the flow of ions across membranes in a controlled manner, allowing researchers to study cellular processes or to develop new technologies for medical applications, drug delivery, and biosensing.
TILLING (Targeting Induced Local Lesions IN Genomes) is a molecular biology technique used to identify mutations within genes of interest. It combines the principles of mutation detection with a high-throughput screening process, allowing researchers to find specific point mutations, such as single nucleotide polymorphisms (SNPs) or small insertions and deletions in genomic DNA.
Transcription is the biological process through which the information encoded in a gene's DNA is copied into messenger RNA (mRNA). This is the first step in gene expression, leading to the synthesis of proteins. Here's a brief overview of the transcription process: 1. **Initiation**: The transcription process begins when the enzyme RNA polymerase binds to a specific region of the DNA called the promoter, which is located near the start of a gene.
Viral transformation refers to the process by which a virus alters the biological properties of a host cell, leading to changes in cell behavior, growth, and function. This phenomenon is particularly significant in the context of certain viruses that can induce oncogenesis, the process by which normal cells become cancerous. Key aspects of viral transformation include: 1. **Oncogenic Viruses**: Some viruses, known as oncogenic or tumor viruses, can insert their genetic material into the host cell's genome.
WikiPathways is an online platform that provides a collaborative environment for the creation and maintenance of pathways related to biological processes. It functions similarly to Wikipedia but is specifically focused on biological pathways, which are sequences of interactions between molecules within cells that result in a specific biological outcome. The platform allows researchers, scientists, and educators to contribute to the knowledge base by adding, editing, and updating pathways. These pathways can include information about metabolic routes, cellular signaling, gene regulation, and more.
Alan M. Frieze is a notable mathematician primarily recognized for his contributions to the fields of combinatorics, graph theory, and algorithms. He is a professor at Carnegie Mellon University and has authored numerous research papers and articles in these areas. His work often focuses on probabilistic methods, approximation algorithms, and the study of random graphs.
Carol S. Woodward is a prominent figure known for her contributions to education and research, particularly in the field of behavior analysis and special education. She has focused on improving the educational experiences and outcomes for students with disabilities. Her work often emphasizes evidence-based practices and interventions that support students in various educational settings.
Nancy Kopell is a noted American mathematician, renowned for her contributions to the fields of dynamical systems, nonlinear dynamics, and mathematical biology. She has done significant work in understanding neural networks and synchronization phenomena, particularly in relation to rhythmic activities in the brain. Kopell has made contributions to the study of how different rhythms can interact, which has implications for understanding various neurological conditions. She has also been recognized for her efforts in promoting mathematics education and outreach, particularly to encourage diversity in the sciences.
Edward Ott is a prominent American physicist, known for his work in the field of chaos theory and nonlinear dynamics. He has made significant contributions to understanding chaotic systems and complex behavior in various physical phenomena. In addition to his research, Ott is recognized for his teaching and for authoring textbooks and papers that have had a substantial impact on the fields of physics and applied mathematics.
Elizabeth B. Dussan V. does not appear to be a widely recognized figure or term in publicly available information up to my last update in October 2023. It’s possible that she could be a private individual, a professional not widely covered in mainstream sources, or a figure relevant to a specific field or community. If you can provide more context or clarify what you're looking for about Elizabeth B. Dussan V.
Helen Moore is a mathematician known for her contributions to various fields of mathematics, particularly in the area of mathematical education and outreach. She has been involved in promoting mathematics and its applications to broader audiences, often focusing on making the subject more accessible and engaging. In addition to her work in education, she may also be recognized for research in specific mathematical areas, though details on her specific achievements can vary.
Hendrik Wade Bode (1905–1982) was an influential American engineer and mathematician, well-known for his contributions to the fields of control systems engineering, signal processing, and telecommunications. He is particularly recognized for developing the Bode plot, a graphical method for analyzing the frequency response of linear time-invariant systems, which is widely used in control theory and engineering to design and analyze systems.
Jill Pipher is a mathematician known for her work in the fields of harmonic analysis, partial differential equations, and mathematical neuroscience. She is a professor at Brown University and has contributed significantly to the understanding of various mathematical concepts and their applications. Pipher is also recognized for her role in promoting women in mathematics and has served in leadership positions within the mathematical community.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 3. Visual Studio Code extension installation.Figure 4. Visual Studio Code extension tree navigation.Figure 5. Web editor. You can also edit articles on the Web editor without installing anything locally.Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.Video 4. OurBigBook Visual Studio Code extension editing and navigation demo. Source. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





