Ciro Santilli @cirosantilli 40

You can connect form an Ubuntu 22.04 host as:When in screen, you can Ctrl + C to kill main.py, and then execution stops and you are left in a Python shell. From there:but be aware of: Raspberry Pi Pico W freezes a few seconds after after screen disconnects from UART.

Other options:

Worked with Kross bicycle (2017) Shimano FC-M311, I managed to remove the crank arm.

Poet, scientists and warriors all in one? Conquerors of the useless.

A wise teacher from University of São Paulo once told the class Ciro Santilli attended an anecdote about his life:It turned out that, about 10 years later, Ciro ended up following this advice, unwittingly.

The proper precise definition of mathematics can be found at: Section "Formalization of mathematics".

The most beautiful things in mathematics are described at: Section "The beauty of mathematics".

This construction takes as input:and it produces an elliptic curve over a finite field of order $p$ as output.

The constructions is used in the Birch and Swinnerton-Dyer conjecture.

To do it, we just convert the coefficients $a$ and $b$ from the Equation "Definition of the elliptic curves" from rational numbers to elements of the finite field.

For example, suppose we have $a=3/4$ and we are using $p=11$.

For the denominator $4$, we just use the multiplicative inverse, e.g. supposing we havewhere $4^{-1}=3\mathrm{mod}11$ because $4\times 3=1\mathrm{mod}11$, related: math.stackexchange.com/questions/1204034/elliptic-curve-reduction-modulo-p

See also: github.com/cirosantilli/awesome-whole-cell-simulation

As of 2019, the silicon industry is ending, and molecular biology technology is one of the most promising and growing field of engineering.

Such advances could one day lead to both biological super-AGI and immortality.

Ciro Santilli is especially excited about DNA-related technologies, because DNA is the centerpiece of biology, and it is programmable.

First, during the 2000's, the cost of DNA sequencing fell to about 1000 USD per genome in the end of the 2010's: Figure 2. "Cost per genome vs Moore's law from 2000 to 2019", largely due to "Illumina's" technology.

The medical consequences of this revolution are still trickling down towards medical applications of 2019, inevitably, but somewhat slowly due to tight privacy control of medical records.

Ciro Santilli predicts that when the 100 dollar mark is reached, every person of the First world will have their genome sequenced, and then medical applications will be closer at hand than ever.

But even 100 dollars is not enough. Sequencing power is like computing power: humankind can never have enough. Sequencing is not a one per person thing. For example, as of 2019 tumors are already being sequenced to help understand and treat them, and scientists/doctors will sequence as many tumor cells as budget allows.

Then, in the 2010's, CRISPR/Cas9 gene editing started opening up the way to actually modifying the genome that we could now see through sequencing.

What's next?

Ciro believes that the next step in the revolution could be could be: de novo DNA synthesis.

This technology could be the key to the one of the ultimate dream of biologists: cheap programmable biology with push-button organism bootstrap!

Just imagine this: at the comfort of your own garage, you take some model organism of interest, maybe start humble with Escherichia coli. Then you modify its DNA to your liking, and upload it to a 3D printer sized machine on your workbench, which automatically synthesizes the DNA, and injects into a bootstrapped cell.

You then make experiments to check if the modified cell achieves your desired new properties, e.g. production of some protein, and if not reiterate, just like a software engineer.

Of course, even if we were able to do the bootstrap, the debugging process then becomes key, as visibility is the key limitation of biology, maybe we need other cheap technologies to come in at that point.

This a place point we see the beauty of evolution the brightest: evolution does not require observability. But it also implies that if your changes to the organism make it less fit, then your mutation will also likely be lost. This has to be one of the considerations done when designing your organism.

Other cool topic include:

It's weird, cells feel a lot like embedded systems: small, complex, hard to observe, and profound.

Ciro is sad that by the time he dies, humanity won't have understood the human brain, maybe not even a measly Escherichia coli... Heck, even key molecular biology events are not yet fully understood, see e.g. transcription regulation.

One of the most exciting aspects of molecular biology technologies is their relatively low entry cost, compared for example to other areas such as fusion energy and quantum computing.