As of 2019, the silicon industry is ending, and molecular biology technology is one of the most promising and growing field of engineering.
Ciro Santilli is especially excited about DNA-related technologies, because DNA is the centerpiece of biology, and it is programmable.
First, during the 2000's, the cost of DNA sequencing fell to about 1000 USD per genome in the end of the 2010's: Figure 2. "Cost per genome vs Moore's law from 2000 to 2019", largely due to "Illumina's" technology.
The medical consequences of this revolution are still trickling down towards medical applications of 2019, inevitably, but somewhat slowly due to tight privacy control of medical records.
Ciro Santilli predicts that when the 100 dollar mark is reached, every person of the First world will have their genome sequenced, and then medical applications will be closer at hand than ever.
But even 100 dollars is not enough. Sequencing power is like computing power: humankind can never have enough. Sequencing is not a one per person thing. For example, as of 2019 tumors are already being sequenced to help understand and treat them, and scientists/doctors will sequence as many tumor cells as budget allows.
Then, in the 2010's, CRISPR/Cas9 gene editing started opening up the way to actually modifying the genome that we could now see through sequencing.
What's next?
Ciro believes that the next step in the revolution could be could be: de novo DNA synthesis.
This technology could be the key to the one of the ultimate dream of biologists: cheap programmable biology with push-button organism bootstrap!
Just imagine this: at the comfort of your own garage, you take some model organism of interest, maybe start humble with Escherichia coli. Then you modify its DNA to your liking, and upload it to a 3D printer sized machine on your workbench, which automatically synthesizes the DNA, and injects into a bootstrapped cell.
You then make experiments to check if the modified cell achieves your desired new properties, e.g. production of some protein, and if not reiterate, just like a software engineer.
Of course, even if we were able to do the bootstrap, the debugging process then becomes key, as visibility is the key limitation of biology, maybe we need other cheap technologies to come in at that point.
This a place point we see the beauty of evolution the brightest: evolution does not require observability. But it also implies that if your changes to the organism make it less fit, then your mutation will also likely be lost. This has to be one of the considerations done when designing your organism.
Other cool topic include:
- computational biology: simulations of cell metabolism, protein and small molecule, including computational protein folding and chemical reactions. This is basically the simulation part of omics.If we could only simulate those, we would basically "solve molecular biology". Just imagine, instead of experimenting for a hole year, the 2021 Nobel Prize in Physiology and Medicine could have been won from a few hours on a supercomputer to determine which protein had the desired properties, using just DNA sequencing as a starting point!
- microscopy: crystallography, cryoEM
- analytical chemistry: mass spectroscopy, single cell analysis (Single-cell RNA sequencing)
Ciro is sad that by the time he dies, humanity won't have understood the human brain, maybe not even a measly Escherichia coli... Heck, even key molecular biology events are not yet fully understood, see e.g. transcription regulation.
One of the most exciting aspects of molecular biology technologies is their relatively low entry cost, compared for example to other areas such as fusion energy and quantum computing.
The orthogonal group is the group of all matrices with orthonormal rows and orthonormal columns Updated 2025-04-24 +Created 1970-01-01
Or equivalently, the set of rows is orthonormal, and so is the set of columns. TODO proof that it is equivalent to the orthogonal group is the group of all matrices that preserve the dot product.
Check out: OurBigBook.com, the best way to publish your scientific knowledge. It's an open source note taking system that can publish from lightweight markup files in your computer both to a multi-user mind melding dynamic website, or as a static website. It's like Wikipedia + GitHub + Stack Overflow + Obsidian mashed up. Source code: github.com/ourbigbook/ourbigbook.
Sponsor me to work on this project. For 200k USD I will quit my job or not get a new job and work on OurBigBook full time for a second year to try and kickstart The Higher Education Revolution. Status: ~44k / 200k USD. At 2M USD I retire/tenure and work on open STEM forever. How to donate: Section "Sponsor Ciro Santilli's work on OurBigBook.com".
I first quit my job 1st June 2024 to work on the project for 1 year after I reached my initial 100k goal mostly via a 1000 Monero donation. For a second follow up year, I increased my requirement to 200k USD to give me more peace of mind. So the total donation so far is 144k, and if I reach a total of 300k USD, then I'll work on the project for a second year. A second year greatly improve chances of success: year one I improved my tech, year two I come guns blazing to solve courses and expand further.
Mission: to live in a world where you can learn university-level mathematics, physics, chemistry, biology and engineering from perfect free open source books that anyone can write to get famous. More rationale: Section "OurBigBook.com"
Explaining things is my superpower, e.g. I was top user #39 on Stack Overflow in 2023[ref][ref] and I have a few 1k+ star educational GitHub repositories[ref][ref][ref][ref]. Now I want to bring that level of awesomeness to masters level Mathematics and Physics. But I can't do it alone! So I created OurBigBook.com to allow everyone to work together towards the perfect book of everything.
My life's goal is to bring hardcore university-level STEM open educational content to all ages. Sponsor me at github.com/sponsors/cirosantilli starting from 1$/month so I can work full time on it. Further information: Section "Sponsor Ciro Santilli's work on OurBigBook.com". Achieving what I call "free gifted education" is my Nirvana.
This website is written in OurBigBook Markup, and it is published on both cirosantilli.com (static website) and outbigbook.om/cirosantilli (multi-user OurBigBook Web instance). Its source code is located at: github.com/cirosantilli/cirosantilli.github.io and also at
cirosantilli.com/_dir and it is licensed under CC BY-SA 4.0 unless otherwise noted.To contact Ciro, see: Section "How to contact Ciro Santilli". He likes to talk with random people of the Internet.
GitHub | Stack Overflow | LinkedIn | YouTube | Twitter | Wikipedia | Zhihu 知乎 | Weibo 微博 | Other accounts
Besides that, I'm also a freedom of speech slacktivist and recreational cyclist. I like Chinese traditional music and classic Brazilian pop. Opinions are my own, but they could be yours too. Tax the rich.
Let's create an educational system with:
- no distinction between university and high school, students just go as fast as they can to what they really want without stupid university entry exams
- fully open source learning material
- on-demand examinations that anyone can easily take without prerequisites
- granular entry selection only for space in specific laboratories or participation in specific novel research projects
I offer:
- online private tutoring for:
- any STEM university course
- passionate younger STEM students (any age) who want to learn university level material and beyond. Can your kid be the next Fields Medalist or Nobel Prize winner? I'm here to help, especially if you are filthy rich! I focus moving students forward as fast as they want on and on producing useful novel tutorials and results
Let your child be my Emile, and me be their Adolfo Amidei, and let's see how far they can go! I will help take your child:and achieve their ambitious STEM goals!- into the best universities
- into the best PhD programs
- educational consulting for institutions looking to improve their STEM courses
- do you know that course or teacher that consistently gets bad reviews every year? I'll work with the teacher to turn the problem around!
- are you looking to create a consistent open educational resources offering to increase your institutions internationally visibility? I can help with that too.
My approach is to:For minors, parents are welcome to join video calls, and all interactions with the student will be recorded and made available to parents.
- propose interesting research projects. The starting point is always deciding the end goal: Section "Backward design"
- learn what is needed to do the project together with the student(s)
- publish any novel results or tutorials/tools produced freely licensed online, and encourage the student to do the same (Section "Let students learn by teaching", digital garden)
I have a proven track of explaining complex concepts in an interesting and useful way. I work for the learner. Teaching statement at: Section "How to teach". Pricing to be discussed. Contact details at: Section "How to contact Ciro Santilli".
I am particularly excited about pointing people to the potential next big things, my top picks these days are:I am also generally interested in:
- quantum computing
- AGI research, in particular AI code generation, automated theorem proving and robotics
- assorted molecular biology technologies
- 20th century physics, notably AMO and condensed matter
- the history of science, and in particular trying to look at seminal papers of a field
Introduction to the OurBigBook Project
. Source. OurBigBook Web topics demo
. Source. The OurBigBook topic feature allows users to "merge their minds" in a "sort by upvote"-stack overflow-like manner for each subject. This is the killer feature of OurBigBook Web. More information at: docs.ourbigbook.com/ourbigbook-web-topics.OurBigBook dynamic article tree demo
. Source. The OurBigBook dynamic tree feature allows any of your headers to be the toplevel h1 header of a page, while still displaying its descendants. SEO loves this, and it also allows users to always get their content on the correct granularity. More information at: docs.ourbigbook.com/ourbigbook-web-dynamic-article-tree.OurBigBook local editing and publishing demo
. Source. With OurBigBook you can store your content as plaintext files in a Lightweight markup, and then publish that to either OurBigBook.com to get awesome multi-user features, or as a static website where you are in full control. More information at: docs.ourbigbook.com/publish-your-content.Top Down 2D continuous game with Urho3D C++ SDL and Box2D for Reinforcement learning by Ciro Santilli (2018)
Source. More information: Section "Ciro's 2D reinforcement learning games". This is Ciro's underwhelming stab at the fundamental question: Can AGI be trained in simulations?. This project could be taken much further.
-------------------------------------
| Force of Will 3 U U |
| --------------------------------- |
| | //////////// | |
| | ////() ()\////\ | |
| | ///_\ (--) \///\ | |
| | ) //// \_____///\\ | |
| | ) \ / / / / | |
| | ) / \ | | / _/ | |
| | ) \ ( ( / / / / \ | |
| | / ) ( ) / ( )/( ) \ | |
| | \(_)/(_)/ /UUUU \ \\\/ | | |
| .---------------------------------. |
| Interrupt |
| ,---------------------------------, |
| | You may pay 1 life and remove a | |
| | blue card in your hand from the | |
| | game instead of paying Force of | |
| | Will's casting cost. Effects | |
| | that prevent or redirect damage | |
| | cannot be used to counter this | |
| | loss of life. | |
| | Counter target spell. | |
| `---------------------------------` |
| l
| Illus. Terese Nelsen |
-------------------------------------Code 1. .
Artist unknown, uploaded December 2014. Part of Section "Cool data embedded in the Bitcoin blockchain" where Ciro Santilli maintains a curated list of such interesting inscriptions.
This was a small project done by Ciro for artistic purposes that received some attention due to the incredible hype surrounding cryptocurrencies at the time. Ciro Santilli's views on cryptocurrencies are summarized at: Section "Are cryptocurrencies useful?".
YellowRobot.jpgJPG image fully embedded in the Bitcoin blockchain depicting some kind of cut material art depicting a yellow robot, inscribed on January 29, 2017.
Ciro Santilli found this image and others during his research for Section "Cool data embedded in the Bitcoin blockchain" by searching for image fingerprints on every transaction payload of the blockchain with a script.
The image was uploaded by EMBII, co-creator of the AtomSea & EMBII upload mechanism, which was responsible for a large part of the image inscriptions in the Bitcoin blockchain.
The associated message reads:This is one of Ciro Santilli's favorite AtomSea & EMBII uploads, as it perfectly encapsules the "medium as an art form" approach to blockchain art, where even non-novel works can be recontextualized into something interesting, here depicting an opposition between the ephemeral and the immutable.
Chiharu [EMBII's Japanese wife] and I found this little yellow robot while exploring Chicago. It will be covered by tar or eventually removed but this tribute will remain. N 41.880778 E -87.629210
At twitter.com/EMBII4U/status/1615389973343268871 EMBII announced that he would be giving off shares of that image on Sup!?, a Bitcoin-backed NFT system he was; making. In December 2023, he gave some shares of the robot to Ciro Santilli.
2010 Wayback Machine archive of starwarsweb.net
. This website was used as one of the CIA 2010 covert communication websites, a covert system the CIA used to communicate with its assets. More details at: Section "CIA 2010 covert communication websites".
Ciro Santilli had some naughty OSINT fun finding some of the websites of this defunct network in 2023 after he heard about the 2022 Reuters report on the matter, which for the first time gave away 7 concrete websites out of a claimed 885 total found. As of November 2023, Ciro had found about 350 of them.
2010 Wayback Machine archive of noticiasmusica.net
. This is another website that was used as one of the CIA 2010 covert communication websites. This website is written in Brazilian Portuguese, and therefore suggests that the CIA had assets in Brazil at the time, and thus was spying on a "fellow democracy".
Although Snowden's revelations made it extremely obvious to the world that the USA spies upon everyone outside of the Five Eyes, including fellow democracies, it is rare to have such a direct a concrete proof of it visible live right on the Wayback Machine. Other targeted democracies include France, Germany, Italy and Spain. More details at: USA spying on its own allies.
Diagram of the fundamental theorem on homomorphisms by Ciro Santilli (2020)
Shows the relationship between group homomorphisms and normal subgroups.
Used in the Stack Exchange answer to What is the intuition behind normal subgroups? One of Section "The best articles by Ciro Santilli".
Spacetime diagram illustrating how faster-than-light travel implies time travel by Ciro Santilli (2021)
Used in the Stack Exchange answer to Does faster than light travel imply travelling back in time?. One of Section "The best articles by Ciro Santilli".
Average insertion time into heaps, binary search tree and hash maps of the C++ standard library by Ciro Santilli (2015)
Source. Used in the Stack Overflow answer to Heap vs Binary Search Tree (BST). One of Section "The best articles by Ciro Santilli".
Top view of an open Oxford Nanopore MinION
. Source. This is Ciro Santilli's hand on the Wikipedia article: en.wikipedia.org/wiki/Oxford_Nanopore_Technologies. He put it there after working a bit on Section "How to use an Oxford Nanopore MinION to extract DNA from river water and determine which bacteria live in it" :-) And he would love to document more experiments like that one Section "Videos of all key physics experiments", but opportunities are extremely rare.
A quick 2D continuous AI game prototype for reinforcement learning written in Matter.js, you can view it on a separate page at cirosantilli.com/_raw/js/matterjs/examples.html#top-down-asdw-fixed-viewport. This is a for-fun-only prototype for Ciro's 2D reinforcement learning games, C++ or maybe Python (for the deep learning ecosystem) seems inevitable for a serious version of such a project. But it is cute how much you can do with a few lines of Matter.js!
HTML snippet:
<iframe src="_raw/js/matterjs/examples.html#top-down-asdw-fixed-viewport" width="1000" height="850"></iframe>There are two cases:
- (topological) manifolds
- differential manifolds
Questions: are all compact manifolds / differential manifolds homotopic / diffeomorphic to the sphere in that dimension?
- Original problem posed, for topological manifolds.AKA: classification of compact 3-manifolds. The result turned out to be even simpler than compact 2-manifolds: there is only one, and it is equal to the 3-sphere.
- for differential manifolds:Counter examples are called exotic spheres.Totally unpredictable count table:is an open problem, there could even be infinitely many. Again, why are things more complicated in lower dimensions??
Born: 1965
Died: 2010+-ish
There are unlisted articles, also show them or only show them.