Ciro Santilli @cirosantilli 35

Main implementations: the same as electronic switches: vacuum tubes in the past, and transistors in the second half of the 20th century.

This technique has managed to determine protein 3D structures for proteins that people were not able to crystallize for X-ray crystallography.

It is said however that cryoEM is even fiddlier than X-ray crystallography, so it is mostly attempted if crystallization attempts fail.

By looking at Figure 1. "A cryoEM image", you can easily understand the basics of cryoEM.

We just put a gazillion copies of our molecule of interest in a solution, and then image all of them in the frozen water.

Each one of them appears in the image in a random rotated view, so given enough of those point of view images, we can deduce the entire 3D structure of the molecule.

Ciro Santilli once watched a talk by Richard Henderson about cryoEM circa 2020, where he mentioned that he witnessed some students in the 1980's going to Germany, and coming into contact with early cryoEM. And when they came back, they just told their principal investigator: "I'm going to drop my PhD theme and focus exclusively on cryoEM". That's how hot the cryo thing was! So cool.

Basically the same remarks as for university, just 10 times more useless, see also: Section "Motivation".

Vs: image: the codomain is the set that the function might reach.

The image is the exact set that it actually reaches.

E.g. the function:could have:

Note that the definition of the codomain is somewhat arbitrary, e.g. $x^2$ could as well technically have codomain:even though it will obviously never reach any value in ${\mathbb{R}}^2$.

The exact image is in general therefore harder to characterize.

Obesity is an extremely serious disease that is very hard to cure, and has deep psychological implications.

Basically a mini-Constellation.

Specific type of Josephson junction. Probably can be made tiny and in huge numbers through photolithography.

Standard from 2011: abcnotation.com/wiki/abc:standard:v2.1

A decent way to write diatonic music as plaintext!

Conversion to MIDI with abcmidi.

No bend/vibratto/slides :-(

Multitrack volatile: abcnotation.com/wiki/abc:standard:v2.1#multiple_voices