Incoming links: Academia is broken
Covers some specific hardcore subjects, notably quantum electrodynamics, in full mathematical detail, e.g.: "Quantum Field Theory Lecture Series" playlist: www.youtube.com/playlist?list=PLSpklniGdSfSsk7BSZjONcfhRGKNa2uou
As of 2020 Dietterich was a condensed matter PhD candidate or post-doc at the University of Minnesota Twin Cities, and he lives in Minnesota, sources:
Unfortunately the channel is too obsessed with mathematical detail (which it does amazingly), and does not give enough examples/application/intuition, which is what would be useful to most people, thus falling too much on the hardcore side of the missing link between basic and advanced.
This channel does have on merit however: compared to other university courses, it is much more direct, which might mean that you get to something interesting before you got bored to death, Section "You can learn more from older students than from faculty" comes to mind.
Videos generally involves short talks + a detailed read-through of a pre-prepared PDF. Dietterich has refused however giving the PDF or LaTeX source as of 2020 on comments unfortunately... what a wasted opportunity for society. TODO find the comment. Sam, if you ever Google yourself to this page, let's make a collab on OurBigBook.com and fucking change education forever man.
Full name as shown in channel content: Samuel Dietterich. Other accounts:
The Ultimate Goal Of My YouTube Channel by Dietterich Labs (2020)
Source. In this video Dietterich gives his ideal for the channel. Notably, he describes how the few experimental videos he has managed to make were done in a opportunistic way from experiments that were happening around him. This resonated with Ciro Santilli's ideas from videos of all key physics experiments.Sam Dietterich interview by Dietterich Labs (2022)
Source. TODO find patience to watch and summarize key points.The Sting Of Soft Corruption: My College Experience by Dietterich Labs
. Source. Academia is broken video.github.com/CovertLab/WholeCellEcoliRelease is a whole cell simulation model created by Covert Lab and other collaborators.
The project is written in Python, hurray!
But according to te README, it seems to be the use a code drop model with on-request access to master. Ciro Santilli asked at rationale on GitHub discussion, and they confirmed as expected that it is to:
- to prevent their publication ideas from being stolen. Who would steal publication ideas with public proof in an issue tracker without crediting original authors? Academia is broken. Academia should be the most open form of knowledge sharing. But instead we get this silly competition for publication points.
- to prevent noise from non-collaborators. But they only get like 2 issues as year on such a meganiche subject... Did you know that you can ignore people, and even block them if they are particularly annoying? Much more likely is that no one will every hear about your project and that it will die with its last graduate student slave.
The project is a followup to the earlier M. genitalium whole cell model by Covert lab which modelled Mycoplasma genitalium. E. Coli has 8x more genes (500 vs 4k), but it the undisputed bacterial model organism and as such has been studied much more thoroughly. It also reproduces faster than Mycoplasma (20 minutes vs a few hours), which is a huge advantages for validation/exploratory experiments.
The project has a partial dependency on the proprietary optimization software CPLEX which is freeware, for students, not sure what it is used for exactly, from the comment in the
requirements.txt the dependency is only partial.This project makes Ciro Santilli think of the E. Coli as an optimization problem. Given such external nutrient/temperature condition, which DNA sequence makes the cell grow the fastest? Balancing metabolites feels like designing a Factorio speedrun.
There is one major thing missing thing in the current model: promoters/transcription factor interactions are not modelled due to lack/low quality of experimental data: github.com/CovertLab/WholeCellEcoliRelease/issues/21. They just have a magic direct "transcription factor to gene" relationship, encoded at reconstruction/ecoli/flat/foldChanges.tsv in terms of type "if this is present, such protein is expressed 10x more". Transcription units are not implemented at all it appears.
Everything in this section refers to version 7e4cc9e57de76752df0f4e32eca95fb653ea64e4, the code drop from November 2020, and was tested on Ubuntu 21.04 with a docker install of
docker.pkg.github.com/covertlab/wholecellecolirelease/wcm-full with image id 502c3e604265, unless otherwise noted. Students must be allowed to progress as fast as they want Updated 2025-01-10 +Created 1970-01-01
One of the main reasons for Section "Students must have a flexible choice of what to learn".
We've created a system where people just wait, and wait, and wait, never really doing what they really want.
They wait through school to get into university.
They wait through university to get to masters.
They wait through masters to get to PhD.
They wait through PhD to become a PI.
And for the minuscule fraction of those that make it, they become fund proposal writers.
And if you make any wrong choice along the, it's all over, you can't continue anymore, the cost would be too great.
So you just become software engineer or a consultant until you die.
Is this the society that we really want?
From True Genius: The Life and Science of John Bardeen Chapter 2 "Roots":
John ([Bardeen].) and Bill ([his brother]) entered the combined seventh-eighth grade at "Uni High," Wisconsin's University High School, in the same year-John from third grade and William from fifth.Established in September 1911, the school had been conceived as a laboratory for training high school instructors and for testing progressive ideas in education. In its philosophy and organization, Uni resembled the Dewey School. The students were accelerated as much as possible to keep lessons challenging. One goal was to "introduce pupils to high school methods and subjects before they reached the 9th grade." The fourth quarter, offered during the summer, allowed students who had missed work or had fallen behind to catch up. It also enabled the brightest students to complete senior high school in only three years...Even with the disruption of Althea’s death, John completed all his Uni High course work by age thirteen. But as he was "a little leery about graduating so young," he and Bill decided to attend Madison Central High School for two years, taking additional mathematics, science, and literature courses not offered at Uni. By the time John had turned fifteen and Bill seventeen, the two had completed every course of interest at Madison Central. There was no longer any reason to postpone entering college. In the fall of 1923 they both entered the freshman class at the University of Wisconsin.
Meanwhile, at the University of Oxford www.theguardian.com/uk/2005/aug/21/highereducation.accesstouniversity Oxford to turn away child prodigiesFUUUUUUUCK. And so, in protecting children, we also rob them of their own future. But the official policy as of 2023 is unchanged at least in theory: uni-of-oxford.custhelp.com/app/answers/detail/a_id/557/~/do-oxford-undergraduate-courses-have-a-minimum-age-requirement%3F Article also mentions Yinan Wang. Can't find his profiles now.
We have been pushed to consider it, not because of concerns about whether it is psychologically healthy for children to study here, but because of child protection laws which have come into play this year for the first time.
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