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Expected positional error at one residue after predicted and true structures are aligned on another residue. Low within-domain values with high between-domain values support more confident internal geometry than relative domain placement. PAE is not a physical residue–residue distance and need not be symmetric.[ref]
PAE: A measure of global confidence in AlphaFold2 predictions by EMBL-EBI. Formal definition and interpretation of inter-domain confidence
The protein-structure prediction system evaluated in CASP14 and reported in 2021. It combines information from related sequences with learned structural relationships, producing coordinates together with confidence estimates rather than a direct experimental structure.[ref]
The probability that an allele eventually occupies every copy at the specified genetic locus under a biological population model. For a rare favorable variant in a suitable large-population, small-effect branching approximation, ; inheritance, reproduction and competition assumptions matter.
A small branched hydrocarbon with no conventional hydrogen-bond acceptor site. Its transfer into water lacks the compensating polar interactions available to oxygen- or nitrogen-containing comparators.
A quadratic integer is an algebraic integer in a quadratic number field , where is a squarefree integer other than . Its ring of integers is if , and otherwise. Thus is a quadratic integer, since it satisfies the monic equation .
For , its conjugate is . Its field trace and field norm are and ; their integrality characterizes the algebraic integers in this degree-two extension. These formulas connect Diophantine equations to arithmetic in a larger ring.
Oxidation with a Dess–Martin periodinane reagent, commonly converting primary alcohols to aldehydes and secondary alcohols to ketones under mild conditions.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.
Figure 3. Visual Studio Code extension installation.
Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. 
- Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact