The astrophysical S factor separates the dominant Coulomb barrier suppression from a charged-particle nuclear reaction cross-section :
Here is relative kinetic energy, is reduced mass, is the fine-structure constant, and are atomic numbers. The astrophysical S factor has units of energy times area. Factoring out a barrier does not remove all nuclear physics: nuclear levels and reaction mechanisms can still make vary strongly.
For a dilute nonrelativistic Maxwell-Boltzmann velocity distribution of relative motion, multiplying the relative-energy density by speed and nuclear reaction cross-section cancels the explicit factors of , giving
Thus the Gamow peak describes a rate-integral kernel, not a histogram of reacting stars or even the unweighted particle population. Plasma screening and departures from the assumed Maxwell-Boltzmann velocity distribution require additional physics.

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