Auxin response factor 1, historically abbreviated ARF1 in this plant context, is a transcription factor characterized for its ability to bind auxin response elements. The 1997 report isolated it using a yeast one-hybrid assay and related its DNA-binding specificity to sequences that conferred an auxin-responsive transcriptional effect.[ref]
ARF1, a transcription factor that binds to auxin response elements by T. Ulmasov and others. Abstract, Science276 (1997), pp.1865–1868; DOI10.1126/science.276.5320.1865.
The study identified an amino-terminal DNA-binding domain and a distinct carboxyl-terminal region associated with interactions between proteins. This supplies a concrete example of modular regulation: contacting a target DNA sequence and contacting another regulator can involve different parts of one protein.[ref]
ARF1, a transcription factor that binds to auxin response elements by T. Ulmasov and others. Abstract: amino-terminal DNA recognition and carboxyl-terminal interaction region.
Experiments with DR5 auxin response elements also showed ARF1 binding and interactions with Aux/IAA proteins. Those observations connect a named factor to a defined regulatory system. They do not turn every auxin response factor into the same protein, nor make DNA binding alone a complete account of the resulting gene expression.[ref]
Aux/IAA proteins repress expression of reporter genes containing natural and highly active synthetic auxin response elements by T. Ulmasov and others. Abstract: ARF1 binding, interaction and reporter repression comparisons.
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