Regulation by changes in free intracellular calcium ion concentration. Calcium signatures are interpreted through calcium-binding sensors and downstream targets; calcium concentration is not itself the final response.
A plant calcium sensor, often abbreviated CBL, that works with a CBL-interacting protein kinase. Sensor localization and partner selection help confer response specificity.
A probe whose measurable output depends on calcium ion binding. Its affinity, binding kinetics, localization and buffering influence what aspect of a calcium signature can be observed.
A localized region with calcium concentration differing from the surrounding compartment, for example close to an open ion channel. A whole-cell average can miss such local signals.
Conversion of a calcium signature into downstream molecular activity. A causal decoding mechanism must explain how sensor kinetics, localization and targets distinguish relevant features of the signal.
The binding, activation and inactivation rates through which a calcium sensor transforms a calcium signature. Slow reversal can integrate closely spaced pulses, whereas rapid reversal permits recovery between them.
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