Cellular reprogramming changes an established cell state so that a different developmental program becomes accessible. Experimentally induced cellular reprogramming must be distinguished from the ordinary progression of cell differentiation. An ovum's cytoplasm can reset aspects of a transferred cell nucleus; this does not mean that a specialized donor normally returns to an early developmental state in its original surroundings. [ref]
Mature cells can be reprogrammed to become pluripotent by Nobel Assembly at Karolinska Institutet. Nobel Assembly, Mature cells can be reprogrammed to become pluripotent, Scientific background: Gurdon nuclear transfer and distinction between differentiation and reprogramming
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