A relatively inaccessible, frequently repressive form of chromatin. Different forms have distinct marks and mechanisms; H3K9 methylation is a major example rather than a universal definition.
Methylation of lysine 9 of histone H3. Different methylation states can recruit specific reader proteins and contribute to heterochromatin regulation.
Extension of a repressive chromatin domain beyond its initial nucleation site. Reader–writer positive feedback can propagate local marks, while histone turnover, opposing activities and chromatin boundaries constrain the domain.
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