A natural cubic spline with the given knots is a function that is polynomial of degree at most three on each interval between consecutive knots and has . With the usual whole-line convention, it extends affinely outside the extreme knots. The word natural refers to these endpoint second-derivative conditions; the interpolation values must be specified separately.
For , direct differentiation on either side of the knot gives
Both one-sided limits of the function and its first two derivatives at are zero, so these formulas are continuous there and
Its third derivative jumps from zero to six, which is permitted for a cubic spline.

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