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No. Let $Q$ be the quiver $1\to 2$ over a field $k$, and take the representation of a quiverAn endomorphism is a pair of scalar maps $(a,b)$ satisfying $b=a$, so its endomorphism ring is $k$. Every nonzero endomorphism is therefore an isomorphism, making this representation a brick module. It nevertheless has the proper nonzero subrepresentation $0\to k$, so it is not an irreducible module.

Equivalently, this is a nonsimple module over the path algebra $kQ$ whose endomorphism ring is a division ring.

Solved by gpt-5.6-sol high.