Diamond knife 2026-11-05
A diamond knife uses a sharpened diamond edge to cut ultrathin sections in ultramicrotomy. The edge's geometry and condition affect the force applied to the specimen and the resulting section. JEOL describes its use for hard inorganic materials and for obtaining uniform sections from resin specimens.[ref]
The knife wedge angle is the angle between the blade faces. It differs from the knife clearance angle, which concerns how the blade is oriented relative to the freshly cut surface. Manufacturer descriptions include and knife families, with the lower-angle design promoted for reduced section compression and a higher-angle design discussed for hard materials.[ref]
Ultra diamond knives by DiATOME. ultra35° and ultra45° manufacturer descriptions; materials applications
For an original ideal symmetric wedge of included angle , the blade width a distance behind the apex isAt , this gives for and for . The wider ideal wedge has about 31% more material behind the edge at that distance. This illustrates a geometry tradeoff; it does not predict a 31% difference in cutting force or assert the exact profile of a commercial knife.
A useful materials experiment compares otherwise matched cuts while recording knife orientation, feed and specimen condition, then measures section dimensions and surface defects. A cut stripe that repeats at the same lateral position suggests an edge-related artifact worth checking. Diamond hardness alone does not guarantee an undamaged edge or an undistorted section.
Guaiacum resin Created 2026-10-31 Updated 2026-11-05
Guaiacum resin is a resin obtained from Guaiacum wood. It is a complex plant product whose solubility and oxidation behavior have been used in historical chemical tests.
Jalap Created 2026-10-31 Updated 2026-11-05
Mistura Guaiaci Created 2026-10-31 Updated 2026-11-05
Mistura Guaiaci is a guaiacum-resin mixture. The dispersed resin and aqueous vehicle have different physical properties.[ref]
The Essentials of Materia Medica and Therapeutics by Alfred Baring Garrod (1865). Mistura Guaiaci, named preparation in the corresponding monograph
Mistura Scammonii Created 2026-10-31 Updated 2026-11-05
Mistura Scammonii is a scammony-containing mixture. A mixed liquid preparation differs from the isolated resin fraction.[ref]
The Essentials of Materia Medica and Therapeutics by Alfred Baring Garrod (1865). Mistura Scammonii, named preparation in the corresponding monograph
Myrrh Created 2026-10-31 Updated 2026-11-05
The seven named mixtures of the 1864 British Pharmacopoeia are Mistura Ammoniaci, Mistura Amygdalae, Mistura Creasoti, Mistura Cretae, Mistura Ferri Composita, Mistura Guaiaci and Mistura Scammonii. Their compositions are as follows; avoirdupois ounces are used for solids and fluid ounces for liquids.
- Mistura Ammoniaci: ammoniacum ¼ avoirdupois ounce, distilled water 8 fluid ounces, rubbed together and strained. Its own gum helps disperse its resin; ammoniacum is not Ammonia. [ref]The Essentials of Materia Medica and Therapeutics by Alfred Baring Garrod (1865). Umbelliferae, part 2, Ammoniacum
- Mistura Amygdalae: compound almond powder 2½ avoirdupois ounces, distilled water 1 Imperial pint. The compound powder is made from sweet almonds 8 parts, sugar 4 parts and gum arabic 1 part by mass. Trituration produces an emulsion. [ref]The Essentials of Materia Medica and Therapeutics by Alfred Baring Garrod (1865). Rosaceae, continued, almond preparations
- Mistura Creasoti: creosote 16 minims, glacial acetic acid 16 minims, Spiritus Juniperi ½ fluid drachm, syrup 1 fluid ounce, distilled water 15 fluid ounces. Here the spirit has the particularly strong 1864 juniper oil content. [ref]The Essentials of Materia Medica and Therapeutics by Alfred Baring Garrod (1865). Hydrocarbons from the destruction of wood by fire, Mistura Creosoti
- Mistura Cretae: prepared chalk and powdered gum arabic, ¼ avoirdupois ounce each; syrup ½ fluid ounce; cinnamon water 7½ fluid ounces. The chalk is suspended, not dissolved. [ref]The Essentials of Materia Medica and Therapeutics by Alfred Baring Garrod (1865). Calcis Carbonas Praecipitata, Creta Praeparata, British mixture
- Mistura Ferri Composita: powdered myrrh 60 grains, potassium carbonate 25 grains, rose water 8 fluid ounces, ferrous sulfate 30 grains, Spiritus Myristicae 1 fluid drachm, sugar 60 grains. Triturate the myrrh with the spirit and potassium carbonate, then add the rose water with sugar, followed by ferrous sulfate; keep the resulting preparation stoppered. Formation of ferrous carbonate and its subsequent oxidation explain why the order and storage matter. [ref]
- Mistura Guaiaci: powdered guaiacum resin ½ avoirdupois ounce, sugar ½ avoirdupois ounce, powdered gum arabic ¼ avoirdupois ounce, cinnamon water 1 Imperial pint. The gum assists dispersion of the poorly water-soluble resin. [ref]The Essentials of Materia Medica and Therapeutics by Alfred Baring Garrod (1865). Zygophyllaceae, resin preparations
- Mistura Scammonii: scammony resin 4 grains with unskimmed milk 2 fluid ounces, triturated into a uniform dispersion. [ref]The Essentials of Materia Medica and Therapeutics by Alfred Baring Garrod (1865). Convolvulaceae, Scammonium, Mistura Scammonii
The category is an official preparation name, not every possible bedside combination of medicines. Camphor water and acacia mucilage are not additional entries under Mistura: the 1864 names are Aqua Camphorae and Mucilago Acaciae. [ref]
The Prescriber's Analysis of the British Pharmacopoeia by John Birkbeck Nevins (1864). pp. 30 and 52–53, mixture names and alterations
Perrin sedimentation experiment Created 2026-10-18 Updated 2026-10-20
A colloidal grain in a liquid is large enough to see with a microscope, yet small enough for thermal motion to compete with its tendency to settle. In the Perrin sedimentation experiment, the equilibrium number density falls with height: a visible miniature atmosphere. Counting grains at different heights measures an energy scale; tracking their Brownian motion measures a transport rate. Connecting both to the same Avogadro constant makes the experiment a quantitative test of kinetic theory. The Wiener measure describes an idealized path law; these measurements instead test a physical model and its material parameters.
Jean Baptiste Perrin's 1909 memoir traces his sedimentation experiments to May 1908. It reports relative counts , , , at heights , , , , and compares radius estimates from Stokes settling velocity, counted grain mass, and rows of touching grains.[ref]
Mouvement brownien et réalité moléculaire by Jean Baptiste Perrin. 1909 memoir, §§15, 20–22; scan pp. 28, 41–49
The 1926 lecture describes resin precipitated from alcohol into water, washed and fractionated by centrifugation to obtain nearly monodisperse gamboge or mastic grains. Diameter and density were measured separately. A sealed slide-and-cover-glass chamber prevented evaporation; a vertical microscope resolved roughly layers through a roughly depth. Refocusing and photographing compared layer populations after equilibrium; changing temperature reversibly changed the distribution.[ref]
Discontinuous Structure of Matter by Jean Baptiste Perrin. Nobel Lectures, Physics 1922–1941; Discontinuous structure of matter, 11 December 1926, pp. 148–150
In Les Atomes (1913), Jean Baptiste Perrin restricts the eyepiece view to fewer than five or six grains and alternates observations between heights. Focus displacement requires a refractive index correction to recover actual layer separation. Horizontal positions were marked with a camera lucida, usually every , and distances calibrated with a micrometer; the polygon joins sampled positions rather than recording the intervening trajectory.[ref]
https://fr.wikisource.org/wiki/Les_Atomes/III. Les Atomes, chapter III, §§61–64
[ref]https://fr.wikisource.org/wiki/Les_Atomes/IV. Les Atomes, chapter IV, §§70–75
Resin Created 2026-10-18 Updated 2026-11-05
Scammony resin Created 2026-10-31 Updated 2026-11-05
Scammony resin is a resinous preparation obtained from scammony material. The isolated resin fraction differs from the crude plant product.