Genome-based peptide fingerprint scanning is a method used in proteomics to identify and characterize proteins based on the peptides they produce. The approach typically involves several key steps: 1. **Genomic Sequencing**: The genome of an organism is sequenced to identify the DNA sequences that code for proteins (genes). 2. **Protein Prediction**: Using bioinformatics tools, the genomic data is analyzed to predict the protein coding sequences and the corresponding peptides.
Genome@home was a distributed computing project aimed at analyzing the human genome and related biological processes. It allowed volunteers to contribute their personal computer processing power to help researchers perform complex computations necessary for genomic analysis, including tasks such as protein folding, simulation of molecular interactions, and other bioinformatics research. The project was similar in concept to other distributed computing initiatives, like SETI@home, wherein users would download a client application to their computers that would run analyses in the background while utilizing idle CPU power.
A heat map is a data visualization technique that uses color to represent the magnitude of values in a dataset. The colors typically range from cooler shades (like blue or green) for lower values to warmer shades (like yellow or red) for higher values. Heat maps are particularly useful for identifying patterns, correlations, and anomalies within data.
Homology modeling, also known as comparative modeling, is a computational technique used in structural biology to predict the three-dimensional structure of a protein based on its sequence similarity to one or more proteins whose structures are known (the template proteins). The underlying assumption of homology modeling is that similar sequences often indicate similar structures, due to the constraints imposed by evolutionary relationships.
The Human Microbiome Project (HMP) is a major research initiative launched by the National Institutes of Health (NIH) in the United States in 2007. Its primary aim is to characterize the microbial communities that inhabit the human body, collectively termed the human microbiome, and to understand their roles in human health and disease.
In silico PCR refers to a computational method used to simulate the polymerase chain reaction (PCR) process using software tools. Instead of performing the physical PCR in a laboratory, in silico PCR allows researchers to predict the outcome of a PCR experiment by modeling the amplification of specific DNA sequences based on known parameters such as DNA templates, primers, and reaction conditions.
The metabolome refers to the complete set of metabolites—small molecules involved in metabolic processes—within a biological sample or system at a specific point in time. Metabolites are the end products of cellular processes and include a wide range of chemical compounds such as amino acids, fatty acids, carbohydrates, vitamins, and nucleotides.
SciCrunch is a platform designed to facilitate research and collaboration in the scientific community. It provides tools and resources for researchers to share data, enhance reproducibility, and improve the organization of scientific information. SciCrunch includes features such as: 1. **Resource Discovery**: The platform helps researchers find biological and scientific resources, including reagents, tools, and databases.
The Protein Data Bank (PDB) is a comprehensive database of three-dimensional structural data of biological molecules, primarily proteins and nucleic acids. It serves as a critical resource for researchers in fields such as biochemistry, molecular biology, and structural biology. The PDB contains information about the spatial arrangement of atoms in these macromolecules, which is crucial for understanding their function, interactions, and roles in various biological processes.
Research in Computational Molecular Biology is an interdisciplinary field that combines biology, computer science, mathematics, and statistics to analyze and interpret biological data, particularly at the molecular level. This area of research focuses on developing algorithms, computational models, and software tools to solve biological problems. Key aspects of research in Computational Molecular Biology include: 1. **Bioinformatics**: The application of computational methods to store, retrieve, and analyze biological data, particularly genomic and proteomic information.
As of my last update in October 2023, Silverquant isn't widely recognized as a major entity in finance, technology, or any other prominent field. It's possible that it could refer to a company, product, or service that has emerged more recently, or it could be a lesser-known entity.
Template modeling score is a specific metric used in the context of protein structure prediction and modeling. It typically indicates the quality or accuracy of a model generated using a template, which is often based on known structures from databases like the Protein Data Bank (PDB). When creating a model using template modeling, researchers align a target sequence (the sequence of the protein being studied) with a known structure (the template) and predict the 3D structure of the target based on this alignment.
A **track hub** is a concept used primarily in the field of bioinformatics and genomics, specifically when working with data visualization and management in platforms like the UCSC Genome Browser. A track hub allows researchers to share and visualize various types of genomic data in a centralized manner. ### Key Features of Track Hubs: 1. **Data Sharing**: Track hubs enable the sharing of genomic data sets, such as gene annotations, variations, expressions, and other relevant biological information among researchers and institutions.
The UCSC Genome Browser is a web-based tool that provides access to a comprehensive set of genomic data and annotations for a variety of organisms, including humans and many model organisms. It is hosted by the University of California, Santa Cruz (UCSC) and is widely used by researchers in genomics, genetics, and molecular biology. The browser allows users to visualize and explore the genome sequences, gene annotations, regulatory elements, comparative genomics data, and other functional elements.
The International Society for Computational Biology (ISCB) Student Council is a group dedicated to supporting and representing the interests of students in the field of computational biology. The council serves as an advocate for student issues within the broader ISCB community and facilitates networking, education, and professional development opportunities for students. The goals of the ISCB Student Council typically include: 1. **Networking**: Creating opportunities for students to connect with peers and professionals in the field, fostering collaborations and friendships.
FinSet, short for "finite set," is a mathematical object that consists of a finite collection of distinct elements. In the context of set theory, a set is simply a collection of objects, which can be anything: numbers, letters, symbols, or even other sets. Finite sets are specifically those that contain a limited number of elements, as opposed to infinite sets, which have an unlimited number of elements.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either https://OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact