Complement component 5a (C5a) is a small but biologically active peptide that is generated during the complement activation pathway, specifically from the cleavage of complement component 5 (C5) by the enzyme C5 convertase. C5a serves as an important inflammatory mediator and plays a crucial role in the immune system by promoting various responses.
A DNA-encoded chemical library (DECL) is a powerful and innovative technology used in drug discovery and biochemistry that combines the principles of chemistry and molecular biology. It enables the rapid and efficient screening of a large number of compounds for potential biological activity. ### Key Features of DNA-Encoded Chemical Libraries: 1. **Linkage to DNA**: In a DECL, small chemical compounds are covalently linked to unique DNA tags.
DNA-templated organic synthesis is an innovative technique that uses DNA molecules as templates to facilitate the synthesis of organic compounds in a highly selective manner. This method exploits the unique properties of DNA, such as its ability to form specific base-pairing interactions and its structural stability, to guide the assembly of small organic molecules.
Erkingul Imankozhoeva is a notable individual from Kyrgyzstan, recognized primarily for her contributions as a social activist and community leader. She has been involved in various initiatives aimed at promoting social justice, women's rights, and community development within her region. Imankozhoeva's work often focuses on empowering marginalized groups and addressing social issues in Kyrgyzstan.
"The Big Bang Theory" Season 8 is the eighth installment of the popular American sitcom created by Chuck Lorre and Bill Prady. It originally aired on CBS from September 22, 2014, to May 14, 2015. The season consists of 24 episodes and continues to follow the lives of physicists Leonard Hofstadter and Sheldon Cooper, along with their friends and fellow scientists, Penny, Howard Wolowitz, and Bernadette Rostenkowski-Wolowitz.
Jack Shaftoe is a fictional character from the historical novel series "The Baroque Cycle" by author Neal Stephenson. The first book in the series is titled "Quicksilver," followed by "The Confusion" and "The System of the World." Jack is depicted as a roguish and adventurous character, often embodying the quintessential swashbuckler archetype.
The Hofstadter Insufficiency is a concept that emerges from the world of mathematical sequences, particularly in the work of Douglas Hofstadter, who is known for his exploration of patterns and strange loops in mathematics and cognition. The term specifically refers to a property of certain recursive sequences, most famously illustrated by Hofstadter's D sequence.
"The Fish Guts Displacement" is an episode from the animated television series "The Big Bang Theory." It is the 14th episode of the show's 9th season, which originally aired on February 4, 2016. In this episode, the character Sheldon Cooper, played by Jim Parsons, struggles with feelings of jealousy and insecurity when he learns that his girlfriend, Amy Farrah Fowler, is experiencing professional success.
"The Big Bang Theory" Season 2 is the second installment of the American sitcom created by Chuck Lorre and Bill Prady. Premiering on September 22, 2008, the season continues to follow the lives of socially awkward physicists Leonard Hofstadter and Sheldon Cooper, along with their roommate and aerospace engineer Howard Wolowitz and their friend, astrophysicist Rajesh Koothrappali.
The Linear Speedup Theorem is a concept in parallel computing that describes the efficiency of a parallel algorithm in relation to the number of processors used. Specifically, it states that if a problem can be perfectly parallelized, then using \( p \) processors can speed up the execution time by a factor of \( p \).
"The Big Bang Theory" Season 5 is the fifth installment of the popular American television sitcom created by Chuck Lorre and Bill Prady. The season originally aired from September 22, 2011, to May 10, 2012, and consists of 24 episodes. In this season, viewers continue to follow the lives of physicists Sheldon Cooper and Leonard Hofstadter, along with their friends Penny, Howard Wolowitz, and Rajesh Koothrappali.
The Pestov–Ionin theorem is a result in the field of mathematical logic that deals with the preservation of certain properties in structures, particularly in the context of countable models. Although it is a specialized topic, the theorem itself is typically discussed within the framework of model theory, which studies the relationships between formal languages and their interpretations (or models).
Descartes' Rule of Signs is a mathematical theorem that provides a way to determine the number of positive and negative real roots of a polynomial function based on the signs of its coefficients. Here’s a concise breakdown of the rule: 1. **Positive Roots**: To find the number of positive real roots of a polynomial \(P(x)\), count the number of sign changes in the sequence of the coefficients of \(P(x)\).
The Gauss–Lucas theorem is a result in complex analysis and polynomial theory concerning the roots of a polynomial. Specifically, it provides insight into the relationship between the roots of a polynomial and the roots of its derivative.
Fejér's theorem is a result in the theory of Fourier series, specifically concerning the convergence of the Fourier series of a periodic function. It states that if \( f \) is a piecewise continuous function on the interval \([-L, L]\), then the sequence of partial sums of its Fourier series converges uniformly to the average of the left-hand and right-hand limits of \( f \) at each point.
Wirtinger's representation theorem and projection theorem are fundamental results in mathematical analysis, particularly in the fields of functional analysis and the theory of Sobolev spaces. They are often applied in the study of harmonic functions, the solution of partial differential equations, and variational problems. ### Wirtinger's Representation Theorem: The Wirtinger representation theorem provides a way to connect the Dirichlet energy of functions to their boundary conditions.
The Friedlander–Iwaniec theorem is a result in number theory, specifically in the area of additive number theory concerning the distribution of prime numbers. It was established by the mathematicians J. Friedlander and H. Iwaniec in the early 1990s.
The Fundamental Theorem on Homomorphisms, often referred to in the context of group theory or algebra in general, states that there is a specific relationship between a group, a normal subgroup, and the quotient group formed by the subgroup. In summary, it describes how to relate the structure of a group to its quotient by a normal subgroup.
The Quillen–Suslin theorem, also known as the vanishing of the topological K-theory of the field of rational numbers, is a fundamental result in algebraic topology and the theory of vector bundles. It states that every vector bundle over a contractible space is trivial. More specifically, it can be expressed in the context of finite-dimensional vector bundles over real or complex spaces.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 3. Visual Studio Code extension installation.Figure 4. Visual Studio Code extension tree navigation.Figure 5. Web editor. You can also edit articles on the Web editor without installing anything locally.Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.Video 4. OurBigBook Visual Studio Code extension editing and navigation demo. Source. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





