Yeast artificial chromosome by Ciro Santilli 35 Updated +Created
Stephen Hawking by Ciro Santilli 35 Updated +Created
While learning black-hole stuff is not on top of Ciro Santilli's priorities, Hawking's spirit is to be admired.
To never give up even when everything seems lost, and still have a sense of humour is respectable.
An ex-physicist colleague who had met Hawking told an anecdote. Hawking was around in the department one day, they said hi and all. But then Hawking wanted to tell a joke. It took like 5 minutes of typing, and you can imagine that things were pretty awkward and the joke's timing was "a bit off". But Hawking did tell the joke nonetheless.
This is also suggested in the The Theory of Everything (2014) film, and therefore likely the biographies.
Wave function by Ciro Santilli 35 Updated +Created
Contains the full state of the quantum system.
This is in contrast to classical mechanics where e.g. the state of mechanical system is given by two real functions: position and speed.
The wave equation in position representation on the other hand encodes speed in "how fast does the complex phase spin around", and direction in "does it spin clockwise or counterclockwise", as described well at: Video "Visualization of Quantum Physics (Quantum Mechanics) by udiprod (2017)". Then once you understand that, it is more compact to just view those graphs with the phase color coded as in Video "Simulation of the time-dependent Schrodinger equation (JavaScript Animation) by Coding Physics (2019)".
Gel electrophoresis by Ciro Santilli 35 Updated +Created
Technique widely used to measure the size of DNA strands, most often PCR output of a region of interest.
A simple sample application is gel electrophoresis alelle determination.
Convergent evolution by Ciro Santilli 35 Updated +Created
Ciro Santilli's cooking by Ciro Santilli 35 Updated +Created
Intelligence analysis by Ciro Santilli 35 Updated +Created
Open-source intelligence by Ciro Santilli 35 Updated +Created
Population genetics by Ciro Santilli 35 Updated +Created
Principle of locality by Ciro Santilli 35 Updated +Created
Born-Oppenheimer approximation by Ciro Santilli 35 Updated +Created
5S ribosomal RNA by Ciro Santilli 35 Updated +Created
Protease by Ciro Santilli 35 Updated +Created
E. Coli K-12 MG1655 operon thrLABC by Ciro Santilli 35 Updated +Created
We can find it by searching for the species in the BioCyc promoter database. This leads to: biocyc.org/group?id=:ALL-PROMOTERS&orgid=ECOLI.
By finding the first operon by position we reach: biocyc.org/ECOLI/NEW-IMAGE?object=TU0-42486.
That page lists several components of the promoter, which we should try to understand!
After the first gene in the codon, thrL, there is a rho-independent termination. By comparing:we understand that the presence of threonine or isoleucine variants, L-threonyl and L-isoleucyl, makes the rho-independent termination become more efficient, so the control loop is quite direct! Not sure why it cares about isoleucine as well though.
TODO which factor is actually specific to that DNA region?
Political correctness by Ciro Santilli 35 Updated +Created
Ciro Santilli believes it generally hurts more than it helps.
Especially when you can't even mention censored things to criticize them. You have to pretend they never existed. So people will forget about them, and do them again in the future.
And when companies do it just to look good, even though it has absolutely no real impact on the lives of those who are discriminated against.
Age of Enlightenment by Ciro Santilli 35 Updated +Created
Bitcoin community by Ciro Santilli 35 Updated +Created
RNA secondary structure by Ciro Santilli 35 Updated +Created
Analogous problem to the secondary structure of proteins. Likely a bit simpler due to the strong tendency for complementary pairs to bind.
Clade by Ciro Santilli 35 Updated +Created
Pinned article: ourbigbook/introduction-to-the-ourbigbook-project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Video 1.
Intro to OurBigBook
. Source.
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
    Video 2.
    OurBigBook Web topics demo
    . Source.
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    • to OurBigBook.com to get awesome multi-user features like topics and likes
    • as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact