Man-made virus!

TODO: if we had cheap de novo DNA synthesis, how hard would it be to bootstrap a virus culture from that? github.com/cirosantilli/cirosantilli.github.io/issues/60

Is it easy to transfect a cell with the synthesized DNA, and get it to generate full infectious viral particles?

If so, then de novo DNA synthesis would be very similar to 3D printed guns: en.wikipedia.org/wiki/3D_printed_firearms.

It might already be possible to order dissimulated sequences online:

The first found and most important known epigenetic marker.

Happens only on adenine and cytosine. Adenine methylation is much less common in mammal than cytosine methylation, when people say "methylation" they often mean just cytosine methylation.

It often happens on promoters, where it inhibits transcription.

Just ignore the electron electron interactions.

Bibliography:

They are actually inheritable! But alleles are rare: www.ncbi.nlm.nih.gov/pmc/articles/PMC5559844

Analogous problem to the secondary structure of proteins. Likely a bit simpler due to the strong tendency for complementary pairs to bind.

A DNA sequence that marks the start of a transcription area.

Converts DNA to RNA.

Make article editing more reasonable. Several bugs in the area.

A sequence of mRNA that can actually be transcribed.

For an example, see E. Coli K-12 MG1655 operon thrLABC.

Multiple different transcription units can be produced by a single operon, see: operon vs transcription unit.

Multiple genes coding for multiple proteins in one transcription unit, e.g. e. Coli K-12 MG1655 gene thrL and e. Coli K-12 MG1655 gene thrA are both prat of the E. Coli K-12 MG1655 operon thrLABC.

Ionizing radiation detectors are devices designed to measure and detect ionizing radiation, which includes particles and high-energy electromagnetic waves that have enough energy to remove tightly bound electrons from atoms, thereby ionizing them. Ionizing radiation includes alpha particles, beta particles, gamma rays, and X-rays. The working principle of these detectors typically involves the interaction of ionizing radiation with matter, which generates ion pairs (electron and positive ion) in a sensing medium.

This was the major final step of fully integrating the OurBigBook CLI into the dynamic website (besides fixing some nasty bugs that escaped passed by me from the previous newsletter).

The implementation was done by "simply" reusing scopes, e.g.: cirosantilli's article about mathematics has scope cirosantilli and full ID cirosantilli/mathematics.

That on the website is equivalent to a local file structure of:

The problem is that a bunch of subdirectory scope operations were broken locally as well, as it simply wasn't a major use case. But now they became a major use case for , so I fixed them.