Discord (software) by Ciro Santilli 40 Updated 2025-07-16
Ciro Santilli's discord ID: cirosantilli#8921. See also: how to contact Ciro Santilli.
You gotta be born after the year 2000 to understand it.
This is becoming more and more popular as a group chat with channels and threads possibility as of 2020.
Very similar to Slack.
Not possible to anonymously join just one server without creating a new account? What's the point of servers then! www.reddit.com/r/discordapp/comments/6gmjl7/changing_nick_before_joining_a_new_server/ Oh, also nicks don't hide your username from the server in any way, you can get the original username by just clicking on the person's username.
No proper threaded discussion without creating new channels? As of 2022 there is kind of a way, but it was a bit obtuse.
As of 2022 they also have a school hub: support.discord.com/hc/en-us/articles/4406046651927-Discord-Student-Hubs-FAQ which auto creates groups by university email access. Good idea, and shows popularity amongst that user group.
Discord is useless if you want to participate in more than one large group because of this. It is impossible to get email notification for selected threads you care about.
Jami (software) by Ciro Santilli 40 Updated 2025-07-16
Ciro Santilli worked on it for a brief time in 2016, when it was still called Ring, before he got fired. :-)
The people were quite nice and the project idea is fine, Ciro hopes they succeed.
Video 1.
Ring - Peer to peer network for real time communication - FOSDEM 2016 by Ciro Santilli
. Source.
Jitsi by Ciro Santilli 40 Updated 2025-07-16
As of 2020: end-to-end encryption optional and turned off as default, and marked as experimental...
Some reviews:
  • the keyboard is kind of crap. Notably the key "a" is very hard to press!!
  • the lack of a sleep state indication LED and "I'm powering on LED" compared to Lenovo is really sad
  • it gets way too hot doing work (Monero bootstrap) with lid closed, likely brought system down
OPSEC: will run only cryptocurrency wallets and nothing else. Will connect to Internet, but never ever to a non clean USB flash drive.
The OPSEC for this machine supposes:
Bootstrap OPSEC:
It must have taken about one week running full time to sync the Monero blockchain which at the time was at about 3.1M blocks! I checked on system explorer, and CPU and internet usage was never maxed out, suggesting simply slow network. But the computer still overheated quite a bit and froze a few times.
The project is written in Python, hurray!
But according to te README, it seems to be the use a code drop model with on-request access to master. Ciro Santilli asked at rationale on GitHub discussion, and they confirmed as expected that it is to:
  • to prevent their publication ideas from being stolen. Who would steal publication ideas with public proof in an issue tracker without crediting original authors? Academia is broken. Academia should be the most open form of knowledge sharing. But instead we get this silly competition for publication points.
  • to prevent noise from non-collaborators. But they only get like 2 issues as year on such a meganiche subject... Did you know that you can ignore people, and even block them if they are particularly annoying? Much more likely is that no one will every hear about your project and that it will die with its last graduate student slave.
The project is a followup to the earlier M. genitalium whole cell model by Covert lab which modelled Mycoplasma genitalium. E. Coli has 8x more genes (500 vs 4k), but it the undisputed bacterial model organism and as such has been studied much more thoroughly. It also reproduces faster than Mycoplasma (20 minutes vs a few hours), which is a huge advantages for validation/exploratory experiments.
The project has a partial dependency on the proprietary optimization software CPLEX which is freeware, for students, not sure what it is used for exactly, from the comment in the requirements.txt the dependency is only partial.
This project makes Ciro Santilli think of the E. Coli as an optimization problem. Given such external nutrient/temperature condition, which DNA sequence makes the cell grow the fastest? Balancing metabolites feels like designing a Factorio speedrun.
There is one major thing missing thing in the current model: promoters/transcription factor interactions are not modelled due to lack/low quality of experimental data: github.com/CovertLab/WholeCellEcoliRelease/issues/21. They just have a magic direct "transcription factor to gene" relationship, encoded at reconstruction/ecoli/flat/foldChanges.tsv in terms of type "if this is present, such protein is expressed 10x more". Transcription units are not implemented at all it appears.
Everything in this section refers to version 7e4cc9e57de76752df0f4e32eca95fb653ea64e4, the code drop from November 2020, and was tested on Ubuntu 21.04 with a docker install of docker.pkg.github.com/covertlab/wholecellecolirelease/wcm-full with image id 502c3e604265, unless otherwise noted.
Telegram (software) by Ciro Santilli 40 Updated 2025-07-16
You can't sync secret chats across devices, Signal handles that perfectly by sending E2EE messages across devices:This is a deal breaker because Ciro needs to type with his keyboard.
Desktop does not have secret chats: www.reddit.com/r/Telegram/comments/9beku1/telegram_desktop_secret_chat/ This is likey because it does not store chats locally, it just loads from server every time as of 2019: www.reddit.com/r/Telegram/comments/baqs63/where_are_chats_stored_on_telegram_desktop/ just like the web version. So it cannot have a private key.
Allows you to register a public username and not have to share phone number with contacts: telegram.org/blog/usernames-and-secret-chats-v2.
Self deleting messages added to secret chats in Q1 2021: telegram.org/blog/autodelete-inv2
Can delete messages from the device of the person you sent it to, no matter how old.
WhatsApp by Ciro Santilli 40 Updated 2025-07-16
Video 1.
WhatsApp founder Jan Koum talks about their Journey by Roots (2017)
Source. Good talk, explains how everything happened in the perfect location at the perfect time: unemployed people who knew how to code, bought an iPhone, the next big platform, at its very beginning, they had just release the required push notifications API, and he travelled a lot and knew how much SMS sucked, especially international.
Obviously with the single intention of killing a competitor.
It is impossible to make money off WhatsApp as it is because of end-to-end encryption.
Facebook just clearly bought it to prevent it from actually growing further and killing facebook.
It is mindblowing that the sale wasn't cancelled due to anti trust.
The outcome of this is that WhatApp will remain with the same feature set forever, while other competitors have been growing, notably Discord and Slack.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either https://OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact