Big excitement picture at: molecular biology technologies.
One of the sequencers made by Oxford Nanopore Technologies.
The device has had several updates since however, notably of the pore proteins which are present in the critical flow cell consumable.
Official documentation: nanoporetech.com/products/minion (archive)
The following images of the device and its peripherals were taken during the experiment: Section "How to use an Oxford Nanopore MinION to extract DNA from river water and determine which bacteria live in it".
Top view of a closed Oxford Nanopore MinION
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Side view of an Oxford Nanopore MinION
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Top view of an open Oxford Nanopore MinION
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How to use an Oxford Nanopore MinION to extract DNA from river water and determine which bacteria live in it Why Oxford Nanopore was used instead of Illumina for the sequencing by 
Ciro Santilli 37 Updated 2025-07-16
Ciro Santilli 37 Updated 2025-07-16At the time of the experiment, Illumina equipment was cheaper per base pair and dominates the human genome sequencing market, but it required a much higher initial investment for the equipment (TODO how much).
The reusable Nanopore device costs just about 500 dollars, and about 500 dollars (50 unit volume) for the single usage flow cell which can decode up to 30 billion base pairs, which is about 10 human genomes 1x! Note that 1x is basically useless for one of the most important of all applications of sequencing: detection of single-nucleotide polymorphisms, since the error rate would be too high to base clinical decisions on.
Compare that to Illumina which is currently doing about an 1000 dollar human genome at 30x, and a bit less errors per base pair (TODO how much).
Other advantages of the MinION over Illumina which didn't really matter to this particular experiment are:
- portability for e.g. to do analysis on the field near infections outbreaks. Compare that to the smallest Illumina sequencer currently available in 2019, the iSeq 100: Figure 1. "Illumina iSeq 100 DNA sequencer".
- long reads which can be necessary for long repetitive regions, see also: Section "Sequence alignment"
Binds an amino acid to the correct corresponding tRNA sequence. Wikipedia mentions that humans have 20 of them, one for each proteinogenic amino acid.
Mostly data driven.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
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Intro to OurBigBook
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