A Drosophila melanogaster has about 135k neurons, and we only managed to reconstruct its connectome in 2023.
The human brain has 86 billion neurons, about 1 million times more. Therefore, it is obvious that we are very very far away from a full connectome.
Instead however, we could look at larger scales of connectome, and then try from that to extract modules, and then reverse engineer things module by module.
This is likely how we are going to "understand how the human brain works".
Some notable connectomes:
- 2019: 1mm cube of mouse brain: www.nature.com/articles/d41586-019-02208-0
- 2023: Drosophila connectome
This game (1 or 2, can't remember) made an impression on Ciro Santilli for some reason.
Only many many years after playing it, after Ciro started getting more interested, did he learn that it was actually an adaptation of the Chinese mega-classic Water Margin.
"Suikoden" is the actual Japenese transliteration for the Chinese name of the original Water Margin novel.
Yet another case of Chinese thing better known in the West as Japanese.
The game puts great emphasis on the concept of the 108 Stars of Destiny, which never left Ciro's mind: making 108 allies, the main collectible of the game, allows you to make a more powerful alliance, and unlock better endings.
This is a general philosophy that Ciro Santilli, and likely others, observes over and over.
Basically, continuity, or higher order conditions like differentiability seem to impose greater constraints on problems, which make them more solvable.
Some good examples of that:
- complex discrete problems:
- simple continuous problems:
- characterization of Lie groups
In 2020 Brazil for example, you are not allowed in theory to obtain a double nationality which you were not allowed to have as a birth right.
This means that Brazilian students e.g. in France, many of whom could easily obtain the French citizenship had to either chose between:Can you guess which option Brazilian students would usually pick?
- giving up their Brazilian citizenship. Who the fuck would do that? Brazilians love their country despite all!
- not getting French citizenship. This meant in France having to come 6 AM once a year to some police station on some suburbia to stamp a piece of paper, plus having your VISA completely dependant on your employer for several years until you could obtain a permanent VISA, making it very hard to change jobs, and putting you in a constantly precarious position
- keeping both citizenships, ignoring Brazilian law, which is extremely unlikely to sue you anyways for this bullshit law, and just hope for the best
As a poor country, you have to allow people to obtain multiple citizenship. Students are not going to go back because they don't have the foreign citizenship. They are just going to have to ensure shittier jobs for a few years, thus diminishing the chances that they will actually lean anything useful to bring back to your country later on.
Claimed to remove metadata from servers unless legally obliged to collect it: www.quora.com/Does-WhatsApp-store-messages-on-its-servers-or-is-all-deleted-after-delivery-and-only-stored-on-recipients-phones/answer/Ciro-Santilli
They've had a few breaches: www.whatsapp.com/security/advisories/
They claim to delete metadata: www.quora.com/Does-WhatsApp-store-messages-on-its-servers-or-is-all-deleted-after-delivery-and-only-stored-on-recipients-phones/answer/Ciro-Santilli
WhatsApp founder Jan Koum talks about their Journey by Roots (2017)
Source. Good talk, explains how everything happened in the perfect location at the perfect time: unemployed people who knew how to code, bought an iPhone, the next big platform, at its very beginning, they had just release the required push notifications API, and he travelled a lot and knew how much SMS sucked, especially international.Official support is abysmal, very focused on MicroPython and their graphical UI.
The setup impossible to achieve as it requires setting up the Yotta, just like the impossible to setup Compile MicroPython code for Micro Bit locally on Ubuntu 22.04 with your own firmware setup.
So we just use github.com/lancaster-university/microbit-samples + github.com/carlosperate/docker-microbit-toolchain:.hex file size for the hello world was 447 kB, much better than the MicroPython hello world downloaded from the website which was about 1.8 MB!
docker pull ghcr.io/carlosperate/microbit-toolchain:latest
git clone https://github.com/lancaster-university/microbit-samples
cd microbit-samples
git checkout 285f9acfb54fce2381339164b6fe5c1a7ebd39d5
# Select a sample, builds one at a time. The default one is the hello world.
cp source/examples/hello-world/* source
# Build and flash.
docker run -v $(pwd):/home --rm ghcr.io/carlosperate/microbit-toolchain:latest yotta build
cp build/bbc-microbit-classic-gcc/source/microbit-samples-combined.hex "/media/$USER/MICROBIT/"If you try it again for a second time from a clean tree, it fails with:presumably because after Yotta died it started using GitHub as a registry... sad. When will people learn. Apparently we were at 5000 API calls per hour. But if you don't clean the tree, you will be just fine.
warning: github rate limit for anonymous requests exceeded: you must log inpubmed.ncbi.nlm.nih.gov/27185558/ A Eukaryote without a Mitochondrial Organelle by Karnkowska et. al (2016)
Contains instructions on how to synthesize MIDI.
Extension: sf2.
Can be imported for example by:
- vmpk
- Csound with
sfload: www.csounds.com/manual/html/sfload.html
This form is not really an inner product in the common modern definition, because it is not positive definite, only a symmetric bilinear form.
All pages below are from the second edition from 2018. It seems that there weren't any changes in the text, the updated preface mentions
As it happens, nearly 15 years have passed since the 1st edition of Power, Sex, Suicide was published, and I am resisting the temptation to make any lame revisions. Some say that even Darwin lessened the power of his arguments in the Origin of Species through his multiple revisions, in which he dealt with criticisms and sometimes shifted his views in the wrong direction. I prefer my original to speak for itself, even if it turns out to be wrong.
This is partly addressed in the preface of the second edition from 2018.
Central thesis:
- there are two sexes because of mitochondria
- the acquisition of mitochondria was one of the most important steps in the evolution of eukaryotes.There are no known eukaryotes which never had mitochondria. Having mitochondria appears to be a requisite for being an eukaryote.Contrast this for example with multicellularity, which is highly polyphyletic.
- Apoptosis is largely regulated by mitochondria
- there are two main theories for how the mitochondria endosymbiosis started:
- parsitic hypothesis of mitochondrial endosymbiosis: a parasitic option rather than cooperative
- hydrogen hypothesis: a cooperative option rather than parasitic
Smaller points:
- 10% of our body weight (dry presumably?) is mitochondria. Also quoted at: www.nature.com/scitable/blog/student-voices/mighty_mitochondria. TODO confirm.
- eukaryotes can do phatocytosis due to their cytoskeleton
- paints a colorful picture of Peter Mitchell. Some Wikipedia edits are warranted!
- it is hard for complex organisms to evolve because longer DNA means longer replication time
- cancer is natural selection gone wrong
- multicellular organisms are not utopias where every cell lives happily. Rather, they are dictatorships, where any dissident is forced to commit seppuku. Lu Xun's petition quote comes to mind.
Nitpicks:
- the book calls ATP synthase "ATPase" in several points, which is confusing because -ase means "something that breaks", and in 2020 parlance, there are ATPases which actually break ATP: en.wikipedia.org/wiki/ATPase. The book itself acknowledges that on page 135:
The ATPase is freely reversible. Under some circumstances it can go into reverse, whereupon it splits ATP, and uses the energy released to pump protons up the drive shaft, back across the membrane against the pressure of the reservoir. In fact the very name ATPase (rather than ATP synthase) signifies this action, which was discovered first. This bizarre trait hides a deep secret of life, and we’ll return to it in a moment.
Some criticisms:
- some of the later chapters are a bit more boring, like the stuff about warm-blooded animals. Perhaps is it that Ciro Santilli is more interested in the molecular aspects than macro
- the author talks about some very recent research at the time. While this does highlight his expertise, some of the points mentioned might still be in a state of flow. This is acknowledged by the author himself on the 2018 updated preface however.
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