This is one of Ciro Santilli's most important principles.
Steve Jobs has a great quote about this. He's totally right on this one!
You've got to start with the customer experience and work backwards to the technology. You can't start with the technology and try to figure out where you're going to sell it.
Steve Jobs Insult Response excerpt from the 1997 WWDC
. Source. TODO understand the context of the question a bit better. It is something to do with an OpenDoc thing and Java.Decide your goal first, and then do whatever is needed to how to reach it.
Don't start randomly learning tech, because that means you will waste a lot of time learning useless stuff.
There is of course some level chicken-and-egg paradox in this, as highlighted by Dilbert, since choosing an achievable goal in the first place requires some level of technical understanding.
Dilbert cartoon about designing a nuclear power plant from user requirements (2002)
Source. This cartoon illustrates well how when doing deep tech and fighting against the laws of physics, you can't just start from user requirements, but you also have to also think "what can we actually get done at all with this new technique".
The best research engineers are able to identify what is just on the cusp of the "possible", but which has the greatest value. This is the endless dance between the tech push, and the market/need pull.
However, it is much more common that people will get way too involved in learning useless stuff and lose sight of the useful end goals.
Rather, take an iterative approach:
- start with an ambitious end goal
- learn a bit of tech to try and reach it
- realize that you can't reach your end goal and pivot a bit to a related end goal that seems more realistic: the side effects of ambitious goals are often the most valuable thing achieved
- loop
There is some truth to the counter argument that "but if you don't spend a lot of time learning the basics, you can never find solutions".
However, these people underestimate your brain. The brain is beautiful, and human intuition is capable of generating interest towards the things that are actually useful to reach your goal. When you feel like learning something related to your goal, by all means, give yourself the time to do so. But this still be much more efficient than just learning random things that other people tell you to learn.
Bibliography:
- Ciro Santilli and many many others believe that backward design is a fundamental principle that should be considered by the educational system rather than wasting 90% of everyone's time with the 90% of mandatory curricula they don't care about:
- notably that school should be personalized and project driven:
- www.cartalk.com/content/rant-and-rave-36 "The New Theory of Learning" by Thomas L. Magliozzi section "Premise III: THE BACKWARDS LEARNING THEORY" says the exact same thing. Ciro actually found this when writing Cool data embedded in the Bitcoin blockchain.
- several well known teaching methods:
- a Coding Horror software specific take on this issue: blog.codinghorror.com/please-dont-learn-to-code/
- x.com/7etsuo/status/1784787045157900697: George Hotz
Everyone I've met who can program well learned it the same way: they had an idea, and then they built it.
Lots of similar ideologies to Ciro Santilli, love it:
- sandymaguire.me/about/:
- he's an idealist
I might best be described somewhere between independent researcher and voluntarily-unemployed bum. At the ripe old age of 27 I decided to quit my highly-lucrative engineering job and decide to focus more on living than on grinding for the man. It's what you might call a work in progress.
- sandymaguire.me/blog/reaching-climbing/: don't be a pussyOne is also reminded of Gwern Branwen. Sandy is also into self-improvement stuff, so even more like Gwern. This is a point Ciro diverges on. Ciro works actively on self-worsening.
Last Friday was my final day at work. According to my facebook profile, I am now "happily retired." As of today, I don't plan to do another day of "traditional work" in my life. That's not to say that I'll be sitting idle playing tiddly winks. I want to build things, to dedicate my life to independent study, and to get really, really good with building communities. I don't have time for any of this "work" stuff that somehow pervades our entire culture, choking our inspiration and sapping our energy away from the things we'd rather be doing.
- he thinks university is useless:
- sandymaguire.me/blog/where-uni-fails/ Where University Fails (2018), mostly talking about backward design
- sandymaguire.me/blog/gatekept/ rejected from Imperial College PhD program due to grade being slightly too low for their stupid requirements, even though he had a referral already, and an amazing CV
- he likes jazz: sandymaguire.me/blog/too-smart/
Other interesting points:
- sandymaguire.me/blog/sandy-runback/ he changed his own name to Sandy because he didn't like it, he was born Alexander
- algebradriven.design/ closed source books though, ouch. At least they seem to have been made with leanpub though, could be worse.
He's a Haskell person.
Scientific Autobiography by Max Planck translated by Frank Gaynor (1949) Updated 2025-04-16 +Created 1970-01-01
Published as Scientific Autobiography and Other Papers by Max Planck translated by Frank Gaynor (1949) which also contained other papers.
This section refers just to the translation of Scientific autobiography by Max Planck (1948).
Funding:
For those that know biology and just want to do the thing, see: Section "Protocols used".
The PuntSeq team uses an Oxford Nanopore MinION DNA sequencer made by Oxford Nanopore Technologies to sequence the 16S region of bacterial DNA, which is about 1500 nucleotides long.
This kind of "decode everything from the sample to see what species are present approach" is called "metagenomics".
This is how the MinION looks like: Figure 1. "Oxford Nanopore MinION top".
The 16S region codes for one of the RNA pieces that makes the bacterial ribosome.
Before sequencing the DNA, we will do a PCR with primers that fit just before and just after the 16S DNA, in well conserved regions expected to be present in all bacteria.
The PCR replicates only the DNA region between our two selected primers a gazillion times so that only those regions will actually get picked up by the sequencing step in practice.
Eukaryotes also have an analogous ribosome part, the 18S region, but the PCR primers are selected for targets around the 16S region which are only present in prokaryotes.
This way, we amplify only the 16S region of bacteria, excluding other parts of bacterial genome, and excluding eukaryotes entirely.
Despite coding such a fundamental piece of RNA, there is still surprisingly variability in the 16S region across different bacteria, and it is those differences will allow us to identify which bacteria are present in the river.
The variability exists because certain base pairs are not fundamental for the function of the 16S region. This variability happens mostly on RNA loops as opposed to stems, i.e. parts of the RNA that don't base pair with other RNA in the RNA secondary structure as shown at: Code 1. "RNA stem-loop structure".
A-U
/ \
A-U-C-G-A-U-C-G C
| | | | | | | | |
U-A-G-C-U-A-G-C G
\ /
U-A
| || |
+-------------++----+
stem loopCode 1.
RNA stem-loop structure
. This is how the 16S RNA secondary structure looks like in its full glory: Figure 5. "16S RNA secondary structure".
Since loops don't base pair, they are less crucial in the determination of the secondary structure of the RNA.
The variability is such that it is possible to identify individual species apart if full sequences are known with certainty.
Literally: West of the Mountain.
This actually happens in spring. But because they are so euphemistic winter had to be removed from the calendar, it gets shifted a left.
Eccentric nerdy slow speaking physicist mostly based in University of Cambridge.
Created the Dirac equation, what else do you need to know?!
QED and the men who made it: Dyson, Feynman, Schwinger, and Tomonaga by Silvan Schweber (1994) chapter 1.3 "P.A.M. Dirac and the Birth of Quantum Electrodynamics" quotes Dirac saying how being at high school during World War I was an advantage, since all slightly older boys were being sent to war, and so the younger kids were made advance as fast as they could through subjects. Exactly the type of thing Ciro Santilli wants to achieve with OurBigBook.com, but without the need for a world war hopefully.
Dirac was a staunch atheist having said during the Fifth Solvay Conference (1927)[ref]:
If we are honest - and scientists have to be - we must admit that religion is a jumble of false assertions, with no basis in reality. The very idea of God is a product of the human imagination. It is quite understandable why primitive people, who were so much more exposed to the overpowering forces of nature than we are today, should have personified these forces in fear and trembling. But nowadays, when we understand so many natural processes, we have no need for such solutions. I can't for the life of me see how the postulate of an Almighty God helps us in any way. What I do see is that this assumption leads to such unproductive questions as why God allows so much misery and injustice, the exploitation of the poor by the rich and all the other horrors He might have prevented. If religion is still being taught, it is by no means because its ideas still convince us, but simply because some of us want to keep the lower classes quiet. Quiet people are much easier to govern than clamorous and dissatisfied ones. They are also much easier to exploit. Religion is a kind of opium that allows a nation to lull itself into wishful dreams and so forget the injustices that are being perpetrated against the people. Hence the close alliance between those two great political forces, the State and the Church. Both need the illusion that a kindly God rewards - in heaven if not on earth - all those who have not risen up against injustice, who have done their duty quietly and uncomplainingly. That is precisely why the honest assertion that God is a mere product of the human imagination is branded as the worst of all mortal sins.
Paul Dirac and the religion of mathematical beauty by Royal Society (2013)
Source. There are unlisted articles, also show them or only show them.