Overview of Shimano brands 2018: www.evanscycles.com/coffeestop/advice/the-complete-guide-to-shimanos-mountain-bike-groupsets-and-their-hierarchy
- Shimano Altus RD-M310: almost cheapest MTB
- Shimano Acera RD-M360: second cheapest MTB
- Shimano Alivio RD-M410: third cheapest MTB
- Shimano Claris: entry 8-speed road bike www.youtube.com/watch?v=6dFQDDg6Wt0
- Shimano Sora: 9-speed road bike bike.shimano.com/en-EU/product/component/sora-r3000.html
- Shimano Tiagra: 10-speed road bike bike.shimano.com/en-EU/product/component/tiagra-4700.html
- Shimano Deore: non-shitty MTB, in increasing performance: M610, M6000, M7000, ...)
- Shimano Tourney; commuter, likely the shittiest of all lines: bike.shimano.com/en-EU/product/component/tourney.html
Instead of trying to dominate the sequencing market and gain trillions of dollars from it, they local British early stage investors were more than happy to get a 20x return on their small initial investments, and sold out to the Americans who will then make the real profit.
And now Solexa doesn't even have its own Wikipedia page, while Illumina is set out to be the next Microsoft. What a disgrace.
Cambridge visitors can still visit the Panton Arms pub, which was the location of the legendary "hey we should talk" founders meeting, chosen due to its proximity to the chemistry department of the University of Cambridge.
In 2021 the founders were awarded the Breakthrough Prize. The third person awarded was Pascal Mayer. He was apparently at Serono Pharmaceutical Research Institute at the time of development. They do have a wiki page unlike Solexa: en.wikipedia.org/wiki/Serono. They paid a 700 million fine in 2005 in the United States, and sold out in 2006 to Merck for 10 billion USD.
Bibliography:
- medium.com/@nick.mccooke/how-we-pioneered-next-generation-dna-sequencing-at-solexa-61bac41aedd2 How We Pioneered Next Generation DNA Sequencing At Solexal by Nick McCooke 2025. This article series could be very interesting.
A network interface controller that does more than just the base OSI model protocols, notably in a programmable way.
- www.nextplatform.com/2022/05/11/intel-unrolls-dpu-roadmap-with-a-two-year-cadence/
- www.trentonsystems.com/blog/what-is-a-smartnic
- blogs.nvidia.com/blog/2021/10/29/what-is-a-smartnic/ "Some are using FPGAs which promise flexibility"
- www.servethehome.com/intel-ipu-exotic-answer-to-industry-dpu/ "Intel IPU is an Exotic Answer to the Industry DPU"
- 2022 www.datacenterdynamics.com/en/news/amd-to-buy-smartnic-firm-pensando-for-19-billion/ "AMD to buy SmartNIC firm Pensando for $1.9 billion"
- www.theregister.com/2022/06/14/alibaba_dpu_cloud/ mentions that Alibaba Cloud created their own.
Hyperscalers Lead The Way To The Future With SmartNICs by The Next Platform (2019)
Source. - youtu.be/kwroXmFJJf0?t=599 financial industry is one of the users, notably high-frequency trading
Associated article: www.nextplatform.com/2019/10/31/hypercalers-lead-the-way-to-the-future-with-smartnics/ mentions that:
Google is widely believed to be working on its own design.
Social media feed that forces you to see posts by non-followed Updated 2025-06-17 +Created 1970-01-01
During the early 2020s, many of the idiotic social media platforms started adding a non optional "feature" of suggesting feed posts by people you don't follow:
It must have been some A/B testing overload that made that decision to try and make things more addictive for everyone. Or perhaps as a way to drive revenue with people paying to cheat the algorithm and boost their posts.
European Union we need you.
Ciro Santilli just always feels that what can be classified as "artificial life" simulators have too much focus on beating more continuous population mechanics, and lack the discrete elements which he feels could be important to AGI: Section "The missing link between continuous and discrete AI".
There is great interest in this direction of research however quite clearly.
The most important on in metabolism internals, everything else gets converted to it before being processed in the .
This is closely linked to the Pauli exclusion principle.
What does a particle even mean, right? Especially in quantum field theory, where two electrons are just vibrations of a single electron field.
Another issue is that if we consider magnetism, things only make sense if we add special relativity, since Maxwell's equations require special relativity, so a non approximate solution for this will necessarily require full quantum electrodynamics.
As mentioned at lecture 1 youtube.com/watch?video=H3AFzbrqH68&t=555, relativistic quantum mechanical theories like the Dirac equation and Klein-Gordon equation make no sense for a "single particle": they must imply that particles can pop in out of existence.
Bibliography:
- www.youtube.com/watch?v=Og13-bSF9kA&list=PLDfPUNusx1Eo60qx3Od2KLUL4b7VDPo9F "Advanced quantum theory" by Tobias J. Osborne says that the course will essentially cover multi-particle quantum mechanics!
- physics.stackexchange.com/questions/54854/equivalence-between-qft-and-many-particle-qm "Equivalence between QFT and many-particle QM"
- Course: Quantum Many-Body Physics in Condensed Matter by Luis Gregorio Dias (2020) from course: Quantum Many-Body Physics in Condensed Matter by Luis Gregorio Dias (2020) give a good introduction to non-interacting particles
Explains how it is possible that everyone observes the same speed of light, even if they are moving towards or opposite to the light!!!
This was first best observed by the Michelson-Morley experiment, which uses the movement of the Earth at different times of the year to try and detect differences in the speed of light.
This leads leads to the following conclusions:
- to length contraction and time dilation
- the speed of light is the maximum speed anything can reach
The "special" in the name refers to the fact that it is a superset of general relativity, which also explains gravity in a single framework.
Since time and space get all messed up together, you have to be very careful to understand what it means to say "I observed this to happen over there at that time", otherwise you will go crazy. A good way to think about is this:
- use Einstein synchronization to setup a bunch of clocks for every position in your frame of reference
- on every point of space, you put a little detector which records events and the time of the event
- each detector can only detect events locally, i.e. events that happen very close to the detector
- then, after the event, the detectors can send a signal to you, who is sitting at the origin, telling you what they detected
Synthesizing the DNA itself is not the only problem however.
You then have to get that DNA into a working living form state so that normal cell processes can continue:
Multicellular questions:
Apparently achieved for the first time in 2021: www.jcvi.org/research/first-self-replicating-synthetic-bacterial-cell by the J. Craig Venter Institute.
There are unlisted articles, also show them or only show them.