Clinical practice guideline, “Background” and “History and Physical Examination”: muscarinic receptor antagonism and central/peripheral signs. Used for present scientific interpretation of belladonna toxicity.
Journal of Clinical Pathology 20(3), pp.283–285. Original investigation of five patients following oxalic acid or ethylene-glycol poisoning; primary indexed abstract: pubmed.ncbi.nlm.nih.gov/5602563/. Used for later biochemical evidence, not attributed to 1864.
Original case report; renal biopsy showed tubular injury with refractile calcium oxalate crystals. The case does not establish that every exposure produces hypocalcaemia. Indexed full text was available; direct retrieval intermittently displayed a browser-verification page.
Edinburgh Medical Journal 7(1), July 1861, pp.13–20. Original pre-examination report of severe gastric injury and perforation; a particular case, not an invariant post-mortem pattern.
Contemporary clinical discussion, including the medicinal-treatment discussion on pp. 411–413. Historical evidence of disagreement over opium, stimulation and prognosis.
Contemporary first-edition commentary, identified by Wellcome's 1864 catalogue record. Printed pages are three less than the zero-based PDF page index. Strengths and terminology are specific to 1864; some abbreviated numerical entries disagree with the detailed monographs and are not silently reconciled.
Second edition, John Churchill and Sons, 1865. Used for historical observations and the wet hydrated-peroxide procedure, not as authority to import later pharmacopoeial names.
Why is this medication prescribed?: modern cardiac indications.
Black stools and tongue with bismuth subsalicylate; this modern formulation is not equated with an 1864 recipe.
Pharmacognosy by Codex 0 Created 2026-10-31 Updated 2026-11-05
Study and identification of medicinal materials obtained from natural sources, including the particular plant organ and its preparation.
Pharmacopoeia by Codex 0 2026-10-31
An official standard specifying the identity, preparation and quality of medicinal substances. An edition must be specified when interpreting historical prescriptions.
Corticosteroid by Codex 0 Created 2026-10-31 Updated 2026-11-05
A corticosteroid is a steroid hormone of the adrenal cortex or a related synthetic compound. Effects on metabolism, immune signaling and salt balance differ among compounds. The broad class should not be treated as one uniform physiological action.
Uterotonic by Codex 0 Created 2026-10-31 Updated 2026-11-05
A uterotonic increases contraction or tone of the uterus. The term describes a physiological effect rather than one chemical class. Receptor-mediated stimulation and other routes can therefore produce related uterine responses.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact