Topics (384k) Articles (398k) Users (410) Discussions (242) Comments (383) Files (13k) New article
Genetical Research5,282–304 (1964). Section1, pp.284–286, especially Fig.1p.285, routes4a/4b and outside-marker outcomes. Primary PDF www.cambridge.org/core/services/aop-cambridge-core/content/view/E11586A6605C2A54C648BACEABECF954/S0016672300001233a.pdf/a-mechanism-for-gene-conversion-in-fungi.pdf . Historical model, not a universal modern biochemical pathway.
Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis by Dong Wang and others by
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Dong Wang, David A. Bushnell, Kenneth D. Westover, Craig D. Kaplan and Roger D. Kornberg, Cell 127(5), 941–954 (2006), DOI 10.1016/j.cell.2006.11.023. Abstract and Figures 1–2: correct NTP positioning, trigger-loop closure and contacts with base, sugar and phosphates. Primary manuscript pmc.ncbi.nlm.nih.gov/articles/PMC1876690/ .
Structural Basis of Transcription: An RNA Polymerase II Elongation Complex at 3.3 Å Resolution by Averell L. Gnatt and others by
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Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome by Erez Lieberman-Aiden and others by
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By Erez Lieberman.
Verified locator: Science 326 (2009), 289–293; DOI 10.1126/science.1181369. Figure 1, Hi-C crosslinking/digestion/end labeling/ligation workflow, and results on chromosome territories and compartments. Published first-author name Erez Lieberman-Aiden; author-lab publication list connects the earlier Erez Lieberman byline.
Structural basis of transcription inhibition by alpha-amanitin and implications for RNA polymerase II translocation by Florian Brueckner and Patrick Cramer by
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Ribosome engineering reveals the importance of 5S rRNA autonomy for ribosome assembly by Shijie Huang and others by
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Huang, Aleksashin, Loveland and others, Nature Communications 11, 2900 (2020), DOI 10.1038/s41467-020-16694-8. Introduction and Figure 1: conserved fold and central protuberance. Results, Figures 3, 6–7: engineered 23S–5S fusion, viability and cryo-EM assembly defects. Primary archive byline: pubmed.ncbi.nlm.nih.gov/32518240/
Quantitative monitoring of gene expression patterns with a complementary DNA microarray by M. Schena and others by
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1995, abstract: robotic printing of cDNA on glass, high-density parallel hybridization and expression measurement.
Regulation of chromatin structure by site-specific histone H3 methyltransferases by S. Rea and others by
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2000, abstract: SUV39H1/Suv39h catalytic activity, histone H3 lysine 9 specificity and dependence on SET with adjoining cysteine-rich regions. Institutional primary text: ora.ox.ac.uk/objects/uuid:da1bc0d8-5a83-42e6-a669-36f1eeae43eb .
Role of DNA-Dependent RNA Polymerase III in the Transcription of the tRNA and 5S RNA Genes by Roberto Weinmann and Robert G. Roeder by
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1974, publisher byline and abstract; alpha-amanitin inhibition of isolated-nucleus transcription compared with separated polymerases.
ZIP1 is a synaptonemal complex protein required for meiotic chromosome synapsis by M. Sym and others by
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Large-scale copy number polymorphism in the human genome by Jonathan Sebat and others by
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2004, abstract and author-hosted primary scan wigweb.cshl.edu/lib/exe/fetch.php?media=sebat_et_al_science_2004.pdf; genomic DNA hybridization detects inherited large-scale copy-number differences.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





