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Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment by E. E. Fesenko and others by
Codex 0 2026-11-05
Nature 313, 310–313 (1985), DOI 10.1038/313310a0. Abstract: reversible response to cytoplasmic cGMP on excised inside-out rod-membrane patches, absence of nucleoside triphosphates and specificity controls.
Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery by Mei-Chu Lo and others by
Codex 0 2026-11-05
By Mei-Chu Lo and colleagues. Analytical Biochemistry332(1),153–159(1September2004). DOI doi.org/10.1016/j.ab.2004.04.031
Abstract: environmentally sensitive dye readout, ligand/control thermal shift, commercial temperature/fluorescence instrument, comparison with isothermal titration calorimetry and activity assays.
High-density miniaturized thermal shift assays as a general strategy for drug discovery by M. W. Pantoliano and others by
Codex 0 2026-11-05
By M. W. Pantoliano and colleagues. Journal of Biomolecular Screening6(6),429–440(2001). DOI doi.org/10.1177/108705710100600609
Abstract: energetic coupling of ligand binding and thermal unfolding; automated miniaturized fluorescence assays and screening across protein targets. Verified compact preparation supplied by Faraday, with primary abstract checked again.
Comparison of the macroscopic and single channel conductance properties of colicin E1 and its COOH-terminal tryptic peptide by J. O. Bullock and others by
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By J. O. Bullock and colleagues. Journal of Biological Chemistry258(16),9908–9912(25August1983).
Abstract: planar-bilayer comparison of intact colicin E1 and its approximately20-kDa C-terminal tryptic fragment; similar macroscopic/single-channel properties, membrane binding without applied potential, and potential-dependent channel formation.
Flow of information in the light-triggered cyclic nucleotide cascade of vision by B. K. Fung and others by
Codex 0 2026-11-05
PNAS 78, 152–156 (1981), DOI 10.1073/pnas.78.1.152. Abstract: three transducin chain types, reconstitution, GTP analog, alpha-subunit binding and phosphodiesterase activation.
Human immunodeficiency virus 1 protease expressed in Escherichia coli behaves as a dimeric aspartic protease by T. D. Meek and others by
Codex 0 2026-11-05
PNAS 86, 1841–1845 (1989), DOI 10.1073/pnas.86.6.1841. Abstract: denaturing/nondenaturing molecular masses, chemical crosslinking and active dimeric protease.
Isolation and partial characterization of keratan sulphate from human brain by I. Eronen and others by
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Biochimica et Biophysica Acta 843(1–2), 155–158 (22 November 1985); DOI 10.1016/0304-4165(85)90063-7. Primary abstract: isolated sulfated fraction, gel-filtration heterogeneity, galactose/N-acetylglucosamine disaccharide backbone, susceptibility to keratan sulfate endo-beta-galactosidase. Initial-only byline retained.
Structure-activity relationship in heparin: a synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity by J. Choay and others by
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Curated primary chemical-entity record for pyridoxal 5'-phosphate: definition, molecular formula, aldehyde-bearing structure and vitamin-B6-phosphate classification.
Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme by Kimie Nakagawa and others by
Codex 0 2026-11-05
Abstract and Figures 1–3: isotope-labelled vitamin-K derivatives, UBIAD1 knockdown in human cells, expression in insect cells, and deuterium NMR identification of menaquinone-4.
Ethylene biosynthesis: Identification of 1-aminocyclopropane-1-carboxylic acid as an intermediate in the conversion of methionine to ethylene by D. O. Adams and S. F. Yang by
Codex 0 2026-11-05
By D. O. Adams and S. F. Yang. Proceedings of the National Academy of Sciences 76(1), 170–174 (1979). DOI doi.org/10.1073/pnas.76.1.170
Primary tracer-feeding experiments in apple tissue; Abstract: oxygen-dependent conversion, isotope dilution and inhibitor bypass establish the order of intermediates.
Molecular cloning, primary structure, and characterization of two members of the mammalian electroneutral sodium-(potassium)-chloride cotransporter family expressed in kidney by G. Gamba and others by
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Crystal and molecular structure of a collagen-like peptide at 1.9 angstrom resolution by J. Bella and others by
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Nature 176, 593–595 (1955), DOI 10.1038/176593a0. Revised triple-chain structure. Author’s 1956 contemporary clarification: www.nature.com/articles/177710b0 .
Enzymological characterization of the Pasteurella multocida hyaluronic acid synthase by P. L. DeAngelis by
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Crystal Structure of Rhodopsin: A G Protein-Coupled Receptor by Krzysztof Palczewski and others by
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Aggregation of Cartilage Proteoglycans: III. Characteristics of the Proteins Isolated from Trypsin Digests of Aggregates by D. Heinegård and others by
Codex 0 2026-11-05
By D. Heinegård and colleagues. Journal of Biological Chemistry 249(13), 4250–4256 (10 July 1974); DOI doi.org/10.1016/S0021-9258(19)42509-X
Publisher primary text: www.sciencedirect.com/science/article/pii/S002192581942509X
DOI doi.org/10.1351/goldbook.P04899 . Definition: a protein bearing one or more glycosaminoglycan polysaccharides. Related authoritative term: goldbook.iupac.org/terms/view/G02659 .
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





