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A role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils by G. L. Hammond and others by
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By G. L. Hammond and colleagues. Journal of Clinical Endocrinology and Metabolism 71(1), 34–39 (July 1990); DOI doi.org/10.1210/jcem-71-1-34
Abstract: neutrophil elastase cleaves human corticosteroid-binding globulin near its C-terminus, with release of more than 80% of bound cortisol in the assay. Cleavage does not inhibit the enzyme.
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin by B. A. Witthuhn and others by
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Cell74(2),227–236 (1993), DOI10.1016/0092-8674(93)90414-l. Abstract: cytokine-receptor-superfamily EPOR lacks intrinsic kinase domain; JAK2 association, phosphorylation and activation following EPO stimulation. Initials retained.
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties by James M. Murphy and others by
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Biochemical Journal457(2),323–334 (2014), DOI10.1042/BJ20131174. Abstract: conserved motif loss, thermal-shift binding assay,31 pseudokinase domains/four binding classes, and contaminating-kinase caveat. Primary full text pmc.ncbi.nlm.nih.gov/articles/PMC5679212/ .
Characterization and sequencing of the active site of 1-aminocyclopropane-1-carboxylate synthase by W. K. Yip and others by
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PNAS87(20),7930–7934 (1990), DOI10.1073/pnas.87.20.7930. Abstract: PLP-dependent ACC synthase, ethylene pathway and substrate-dependent inactivation. pmc.ncbi.nlm.nih.gov/articles/PMC54865/ .
Agarose Derivatives for Purification of Protein by Affinity Chromatography by Pedro Cuatrecasas by
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Citrulline, CHEBI:18211: chemical-class definition and structure. The biological L-enantiomer record www.ebi.ac.uk/chebi/CHEBI:16349 gives formula, stereochemistry and the relation to the zwitterion.
The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1 by M. Soriano-Garcia and others by
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Vitamin K dependent modifications of glutamic acid residues in prothrombin by J. Stenflo and others by
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PNAS71(7),2730–2733 (1974); DOI10.1073/pnas.71.7.2730. Authors J. Stenflo, P. Fernlund, W. Egan and P. Roepstorff. Abstract: anomalous electrophoretic mobility, nuclear magnetic resonance and mass spectrometry identified gamma-carboxyglutamic acid in prothrombin.
Amino-terminal sequences of two polypeptides from human serum with nonsuppressible insulin-like and cell-growth-promoting activities: evidence for structural homology with insulin B chain by E. Rinderknecht and R. E. Humbel by
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PNAS73(12),4379–4381 (1976), DOI10.1073/pnas.73.12.4379. Abstract: amino-terminal sequences, 22 identical positions among first31, comparison to insulin B chain and proposed insulin-like-growth-factor designation. pmc.ncbi.nlm.nih.gov/articles/PMC431462/ . Initials retained.
ChEBI definition and variable-chain structure, CHEBI:17517. The conjugate-base entry www.ebi.ac.uk/chebi/CHEBI:60523 identifies phosphatidylglycerol(1−).
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme by D. S. Bredt and S. H. Snyder by
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D. S. Bredt and S. H. Snyder, PNAS 87(2), 682–685 (1990), DOI 10.1073/pnas.87.2.682. Abstract: arginine/citrulline conversion, NADPH and calcium/calmodulin dependence, affinity purification from rat cerebellum. Historical native-oligomer inference is not adopted. pmc.ncbi.nlm.nih.gov/articles/PMC53329/
Mechanism of activation of protein kinase JAK2 by the growth hormone receptor by Andrew J. Brooks and others by
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Andrew J. Brooks and colleagues, Science 344 (2014), 1249783, DOI 10.1126/science.1249783. Abstract: FRET measurement of JAK2-binding-motif positioning, engineered domain substitutions, transmembrane modeling and kinase/pseudokinase-domain arrangement. Mechanistic model rather than crystal observation of every signaling step.
Fibrinopeptides A and B release in the process of surface fibrin formation by Tomas Riedel and others by
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Verified locator: Blood117(5),1700–1706 (2011), DOI10.1182/blood-2010-08-300301; online24November2010. Introduction: 16/14-residue peptides and knob/hole locations. Methods: adsorbed fibrinogen in polystyrene wells, thrombin incubation, HPLC. Abstract/Figs4–5: altered FpB lag and release from surface-bound protein.
Synthetic peptide derivatives that bind to fibrinogen and prevent the polymerization of fibrin monomers by Andrew P. Laudano and Russell F. Doolittle by
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Verified locator: PNAS75(7),3085–3089 (1978), DOI10.1073/pnas.75.7.3085. Abstract: Gly-Pro-Arg-Pro binding to fibrinogen and fragment D, absent binding to fragment E, and inhibition of fibrin polymerization.
Factor-V activation by thrombin and its role in prothrombin conversion by J. C. Giddings and A. L. Bloom by
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Verified locator: British Journal of Haematology 29(2),349–364 (1975), DOI10.1111/j.1365-2141.1975.tb01829.x. Abstract: purified factors, gel chromatography and antibody identification of membrane-associated complexes; thrombin pretreatment increases factor-V activity.
Human growth hormone and extracellular domain of its receptor: crystal structure of the complex by A. M. de Vos and others by
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By A. M. de Vos and others; primary byline and publication details verified on the journal's PubMed record. Science 255(5042), 306–312 (17 January 1992). DOI: doi.org/10.1126/science.1549776
Verified locator: abstract, 2.8-angstrom crystal structure, one hormone molecule with two receptor extracellular domains and distinct binding surfaces. Primary deposited structure: www.rcsb.org/structure/3HHR . The crystallographic complex does not alone establish every step of receptor activation in living cells.
Steady state kinetic parameters for the thrombin-catalyzed conversion of human fibrinogen to fibrin by D. L. Higgins and others by
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Crystal Structure of Prothrombin Reveals Conformational Flexibility and Mechanism of Activation by Nicola Pozzi and others by
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Accepted name, reaction and comments: factor X activation by limited proteolysis; prothrombin cleavage with factor Va, calcium and phospholipids. Avoid assuming one cleavage order under every experimental condition.
Channelrhodopsin-2, a directly light-gated cation-selective membrane channel by Georg Nagel and others by
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PNAS 100(24), pp.13940–13945; DOI 10.1073/pnas.1936192100. Original paper, abstract: functional expression in Xenopus oocytes and mammalian cells; directly light-switched cation conductance, desensitization. Primary archive pmc.ncbi.nlm.nih.gov/articles/PMC283525/ .
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





