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Attenuation in bacterial gene regulation regulates downstream transcription through formation of alternative RNA structures during transcription. In the tryptophan example, biological translation of a leader peptide influences which structure forms; the immediate decision is transcription termination.
A regulatory factor that helps a transcription activator increase target gene expression, often through interactions with chromatin or the RNA polymerase machinery.
Regulation through a diffusible product acting at another genetic locus, contrasted with a local cis-regulatory sequence.
Differential gene expression is a difference in expression between specified biological conditions or biological populations. A comparison must define the measured quantity, such as transcript abundance or protein production. Increased abundance can arise from increased synthesis or decreased removal, and mixed tissues can change through altered cell composition. Replication and a suitable statistical model are needed to separate a reproducible difference from sampling variation. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapter 7, Control of Gene Expression: expression regulation at multiple stages
A relationship between genes arising through duplication. It differs from orthology, which concerns divergence through lineage splitting.
A tandem duplication creates an additional copy of a genomic segment adjacent to the original. A duplicated gene can initially increase dosage, after which the copies can diverge or one can lose function. Adjacency distinguishes tandem copies from duplicates moved to distant positions. Repeated near-identical copies can also complicate genome assembly because short sequencing reads may not identify which copy they came from. [ref]
Talking Glossary of Genomic and Genetic Terms by NHGRI. Duplication entry
Creation of adjacent copies of a gene or genomic segment. Subsequent divergence can produce a local gene family while preserving aspects of ancestral order.
Duplication of the full genomic complement. gene loss, subfunctionalization and neofunctionalization can obscure the original duplicated organization.
An antheridium is a structure that produces male gametes in relevant plant and other lineages. In bryophytes and many ferns, antheridia on the gametophyte produce motile sperm.
A suitable water connection allows those sperm to reach an archegonium. Release and transport of spores can occur under different conditions, so efficient spore dispersal does not remove the later water requirement for fertilization.
An archegonium is an egg-producing reproductive structure in several land-plant lineages, including bryophytes and many ferns. It belongs to the gametophyte generation and contains the ovum reached by sperm during fertilization.
After fertilization, the developing sporophyte can remain associated with the maternal gametophyte. This links reproductive anatomy to maternal support of a new generation without making the two generations one genetically identical individual.
A name commonly used for a fern gametophyte. A small photosynthetic free-living body is a useful example, but not a description of every fern gametophyte.
An impartial game is a game in which both players have the same legal moves from any given position. Under the normal-play convention, a player with no legal move loses. For finite games without draws, Grundy numbers encode positions for the Sprague-Grundy theorem.
The convention that a player unable to move loses. In a finite impartial game without draws, a position is winning exactly when it has a move to a losing position.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





