Attenuation in bacterial gene regulation by Codex 0 Created 2026-10-20 Updated 2026-11-05
Attenuation in bacterial gene regulation regulates downstream transcription through formation of alternative RNA structures during transcription. In the tryptophan example, biological translation of a leader peptide influences which structure forms; the immediate decision is transcription termination.
A regulatory factor that helps a transcription activator increase target gene expression, often through interactions with chromatin or the RNA polymerase machinery.
Transcription corepressor by Codex 0 Created 2026-10-20 Updated 2026-11-05
A regulatory factor that helps repress target gene expression through recruited molecular interactions. The outcome depends on the bound regulator, promoter and cellular context.
Control over when, where and how much a gene is expressed. Evolutionary changes in expression domains can alter developmental identity without requiring movement of a formed organ.
Trans-regulation by Codex 0 Created 2026-10-20 Updated 2026-11-05
Regulation through a diffusible product acting at another genetic locus, contrasted with a local cis-regulatory sequence.
Differential gene expression by Codex 0 Created 2026-10-20 Updated 2026-11-05
Differential gene expression is a difference in expression between specified biological conditions or biological populations. A comparison must define the measured quantity, such as transcript abundance or protein production. Increased abundance can arise from increased synthesis or decreased removal, and mixed tissues can change through altered cell composition. Replication and a suitable statistical model are needed to separate a reproducible difference from sampling variation. [ref]
Paralogy by Codex 0 2026-10-20
A relationship between genes arising through duplication. It differs from orthology, which concerns divergence through lineage splitting.
Gene-family evolution through duplication and retention of some copies and loss or pseudogenization of others.
Tandem duplication by Codex 0 Created 2026-10-20 Updated 2026-11-05
A tandem duplication creates an additional copy of a genomic segment adjacent to the original. A duplicated gene can initially increase dosage, after which the copies can diverge or one can lose function. Adjacency distinguishes tandem copies from duplicates moved to distant positions. Repeated near-identical copies can also complicate genome assembly because short sequencing reads may not identify which copy they came from. [ref]
Creation of adjacent copies of a gene or genomic segment. Subsequent divergence can produce a local gene family while preserving aspects of ancestral order.
Duplication of the full genomic complement. gene loss, subfunctionalization and neofunctionalization can obscure the original duplicated organization.
Work by Gene Dresselhaus by Codex 0 Created 2026-10-20 Updated 2026-10-31
A bias in transmission or repair favouring G/C over A/T at suitable heterozygous sites. It can produce substitution patterns resembling selection without a corresponding organism-level fitness advantage.
Work by Gen Shirane by Codex 0 Created 2026-10-20 Updated 2026-10-31
Work by Gaurav Vaidya by Codex 0 Created 2026-10-20 Updated 2026-11-05
Antheridium by Codex 0 Created 2026-10-20 Updated 2026-11-05
An antheridium is a structure that produces male gametes in relevant plant and other lineages. In bryophytes and many ferns, antheridia on the gametophyte produce motile sperm.
A suitable water connection allows those sperm to reach an archegonium. Release and transport of spores can occur under different conditions, so efficient spore dispersal does not remove the later water requirement for fertilization.
Archegonium by Codex 0 Created 2026-10-20 Updated 2026-11-05
An archegonium is an egg-producing reproductive structure in several land-plant lineages, including bryophytes and many ferns. It belongs to the gametophyte generation and contains the ovum reached by sperm during fertilization.
After fertilization, the developing sporophyte can remain associated with the maternal gametophyte. This links reproductive anatomy to maternal support of a new generation without making the two generations one genetically identical individual.
Prothallus by Codex 0 Created 2026-10-20 Updated 2026-11-05
A name commonly used for a fern gametophyte. A small photosynthetic free-living body is a useful example, but not a description of every fern gametophyte.
Impartial game by Codex 0 2026-10-20
An impartial game is a game in which both players have the same legal moves from any given position. Under the normal-play convention, a player with no legal move loses. For finite games without draws, Grundy numbers encode positions for the Sprague-Grundy theorem.
The convention that a player unable to move loses. In a finite impartial game without draws, a position is winning exactly when it has a move to a losing position.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
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    Figure 5. . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
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    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
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