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An aldohexose is a six-carbon aldose: its open-chain reference form has an aldehyde group at C1. Glucose is an example.^[ref]

The unmodified open-chain skeleton has four stereocenters, C2–C5, giving $2^4=16$ stereoisomers, or eight enantiomer pairs. Fixing the C5 hydroxy group on the right leaves $2^3=8$ D forms; D-glucose's right/left/right/right pattern selects one. An aldohexose label therefore specifies less than a particular sugar name, and a molecular formula specifies less still. The existing glucose article checks its chemical atom inventory; monosaccharide ring-chain interconversion follows those same numbered carbon positions into a ring.

Glucose is a monosaccharide with molecular formula ${\mathrm{C}}_6{\mathrm{H}}_{12}{\mathrm{O}}_6$. Its familiar biological form, D-glucose, is an aldohexose. In the open-chain Fischer projection, $\mathrm{CHO}$ is at the top and ${\mathrm{CH}}_2\mathrm{OH}$ at the bottom; the hydroxy groups at C2, C3, C4, and C5 point right, left, right, right. This full pattern distinguishes D-glucose from other six-carbon aldehyde sugars. See McMurry, Organic Chemistry, 25.4: configurations of the aldoses.

The molecular formula can be checked directly: one $\mathrm{CHO}$ group, four $\mathrm{CHOH}$ groups, and one ${\mathrm{CH}}_2\mathrm{OH}$ group give six carbon, twelve hydrogen, and six oxygen chemical atoms. All four interior carbon positions are stereocenters in this open-chain structure. Neither their orientations nor the arrangement of chemical bonds can be recovered from the molecular formula alone.

In water, glucose exists mainly in six-membered rings in chemical equilibrium with a small amount of open-chain glucose. Ring closure connects the hydroxy group at C5 to the aldehyde carbon at C1; the ring contains five carbon chemical atoms and one oxygen, with C6 outside it. No chemical atoms are lost, so the molecular formula remains ${\mathrm{C}}_6{\mathrm{H}}_{12}{\mathrm{O}}_6$. See McMurry, Organic Chemistry, 25.5: cyclic structures of monosaccharides.

Glucose is useful both as a substrate in cellular metabolism and as a building block of polysaccharides. Cellulose chains assembled from glucose units help support plant cell walls. The same small sugar thus connects chemical fuel to a structural material; its role depends on how it is transformed or linked. See Cooper, The Cell: A Molecular Approach, the molecular composition of cells.

A monosaccharide is a single-unit carbohydrate that cannot be split into smaller sugars by hydrolysis. Ribose, deoxyribose, and glucose are examples. The unit is a whole molecule containing many chemical atoms; a disaccharide instead contains two linked monosaccharide units.^[ref]

Classification combines carbon count with open-chain connectivity. An aldose has an aldehyde group; a ketose has a ketone group. Thus glucose is an aldohexose, while fructose is a six-carbon ketose. These names describe the open-chain reference forms even when cyclic forms predominate in water.^[ref]

Check the distinction by counting the groups in the drawings. Open-chain glucose contains one $\mathrm{CHO}$, four $\mathrm{CHOH}$ and one $\mathrm{C}{\mathrm{H}}_2\mathrm{OH}$ group. Open-chain fructose contains two $\mathrm{C}{\mathrm{H}}_2\mathrm{OH}$, three $\mathrm{CHOH}$ and one $\mathrm{C}=\mathrm{O}$ group. The respective hydrogen totals are $1+4(2)+3=12$ and $2(3)+3(2)=12$; each structure also has six carbon and six oxygen chemical atoms. Their shared molecular formula ${\mathrm{C}}_6{\mathrm{H}}_{12}{\mathrm{O}}_6$ therefore cannot identify the carbonyl group position or the stereochemistry.

The beauty is that a familiar sugar name can embrace an interconverting family of forms. Monosaccharide ring-chain interconversion connects those drawings to mutarotation, a change visible with polarimetry. Spatial arrangement also matters to biology: an enzyme's active site encounters a particular arrangement of hydroxy groups, rather than merely an inventory of chemical atoms. The existing enzyme and chirality articles explain that recognition principle.

In chemical usage, sugars commonly means small carbohydrates, including single-unit monosaccharides and two-unit disaccharides. Glucose, ribose, and deoxyribose are monosaccharides. Cellulose is instead a polysaccharide assembled from many glucose units. The distinction counts chemically linked units; it does not classify every carbohydrate by sweetness or biological role. See Clark, Douglas and Choi, Biology 2e, 3.2: carbohydrates.

A useful first description of a monosaccharide asks how many carbon chemical atoms it contains and what its open-chain structure is. Ribose is an aldopentose, a five-carbon aldehyde sugar; glucose is an aldohexose, with six carbon chemical atoms. A Fischer projection then records the stereochemistry, information missing from the molecular formula. See McMurry, Organic Chemistry, 25.1: carbohydrate classification.