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Ploidy counts complete sets of chromosomes in a cell nucleus. Write $n$ for the number of chromosomes in one set: haploid means one set, diploid two. DNA replication produces sister chromatids without changing ploidy.^[ref]

Consider an illustrative species with $2n=6$, hence $n=3$. One set contains three distinguishable chromosome types, $A,B,D$; the diploid cell nucleus contains two homologous chromosomes of each type. Labels describe chromosome identity, not particular alleles. Let $C$ be the Nuclear DNA content of one unreplicated set. All entries below refer to one completed product of division, or the starting cell nucleus, rather than the sum over products. Here “chromatid count” includes the single DNA copy in each unreplicated chromosome.

The arithmetic follows the allocation rules. DNA replication replaces each of six single copies with two associated sister chromatids: $6\times 2=12$ copies still grouped as six chromosomes. Meiosis I allocates one homologous chromosome of every type to each product: three replicated chromosomes, with $3\times 2=6$ copies. Meiosis II allocates one copy from each pair of sister chromatids to each final product: three single-copy chromosomes. Compare meiotic DNA content for the general symbolic bookkeeping. Chromosomal crossover can change the alleles on a chromatid without changing these counts when exchanges preserve material.

Keeping ploidy, chromosome count and Nuclear DNA content separate makes the beauty of meiosis explicit: copying supplies material for two divisions, while sorting determines which complete sets each product inherits. It also prevents interpreting a doubled DNA signal as evidence of an extra homologous chromosome set.

Sister chromatids are the paired chromatids originating from DNA replication of the same chromosome.

A somatic mutation occurs in a body-cell lineage outside the germline mutation route. Its descendant biological cells can inherit it through DNA replication, even though it is not transmitted through gametes. Thus heritability within a cell lineage differs from inheritance between sexually reproducing organisms.

During S phase, nuclear DNA replication produces paired sister chromatids. DNA content rises from $2C$ to $4C$, while the chromosome count remains $2n$.