For positive thermal diffusivity , thermal conductivity and length , subtract the stationary solution . The remainder satisfies the heat equation with a homogeneous Dirichlet boundary condition at zero and a homogeneous Neumann boundary condition at . The mixed Dirichlet-Neumann modes on an interval are , where . Thus for an initial temperature profile ,
For zero initial temperature, . The series gives the initial profile in the usual Fourier series sense and a smooth solution for . If , the zero initial profile does not satisfy the prescribed endpoint derivative at : the temperature can be continuous there without its spatial derivative extending continuously to that corner. The sign describes incoming heat flux, since the outward conductive heat flux is .
Use the mixed Dirichlet-Neumann modes on an interval. To justify their Fourier series, extend evenly across to , then oddly across , and repeat with period four. The condition makes the odd extension continuous, and makes the even reflection continuously differentiable. The resulting periodic function has a convergent Fourier sine series. Reflection about eliminates the even sine harmonics, leaving
Alternatively these values follow directly from and . Fourier orthogonality gives
The extension argument also supplies completeness, not merely orthogonality, of this Fourier sine basis.
Expand the forcing as . Product-to-sum and integration by parts give
Each mode of the differential operator has eigenvalue . Hence, for real , the solution is
The coefficients are , so the series and its first two differentiated series converge uniformly. Therefore it solves the equation and the boundary conditions term by term. Uniqueness follows by multiplying the homogeneous equation by its real solution and integrating: the boundary terms vanish and , forcing .
Put . Linearizing the morphogen reaction-diffusion equation at gives
Seek separated modes . Then
The mixed Dirichlet-Neumann modes on an interval are
Indeed, the Dirichlet condition selects sine functions, while the Neumann condition requires . Their growth rates are
The largest growth rate is the lowest mode,
Linear stability requires , after which all higher modes also decay. Therefore the critical length for a linearly growing morphogen is
Equality gives a neutral lowest mode, while a larger domain is linearly unstable.
Subtract the constant steady state profile: set . Then
The last equation follows from Fourier's law and zero heat flux at the insulated end. For a nonzero separated solution , separation of variables gives
To see that for a nonzero eigenfunction, multiply the spatial equation by and use integration by parts:
Both boundary terms vanish. If the right side were zero, would be constant and would make it zero. Thus write with . Solving gives , and requires . The mixed Dirichlet-Neumann modes on an interval therefore have
The eigenvalues of are ; are their positive square roots. By superposition, with coefficients for which the resulting series and its required derivatives converge at positive times,
The eigenfunctions are orthogonal on and have squared norm . Expanding the initial excess temperature gives
Thus the requested temperature is
At the insulated endpoint cancels the alternating coefficient sign, leaving
Every summand is positive. The endpoint temperature never drops below ; it decreases towards as and starts at .
For completeness, the Sturm-Liouville eigenfunction expansion gives the initial profile in the sense. Here the coefficients are absolutely summable, so the Weierstrass M-test also gives uniform convergence on , and the initial values are recovered everywhere. For positive times the exponential factors justify all required termwise derivatives, giving a classical solution. There is, however, an initial incompatibility with a Neumann boundary condition at : the initial slope is , while the insulated Neumann boundary condition requires zero slope for . The temperature is continuous to the initial edge, but cannot extend continuously to that corner. One must not differentiate the initial series term by term at .
For a nonzero separated solution , separation of variables gives and . The endpoint conditions require and . Thus the mixed Dirichlet-Neumann modes on an interval have , . Their squared L2 norms are , so the initial Fourier coefficients are
The integration uses and . Therefore
At positive time the series can be differentiated termwise and satisfies both homogeneous endpoint conditions for . At time zero it recovers , so recovers the initial zero temperature. If , the prescribed derivative at is incompatible with differentiating the initial zero profile; the temperature is still continuous there, while its spatial derivative has a corner layer. At long times the decaying modes leave .
Figure 1.
Heating a bar through one end while the other end stays at zero temperature
. Original dimensionless temperature profiles at several diffusion times. The eventual linear profile has the imposed unit derivative at the heated end. Details.