Suppose a nonconstant periodic orbit exists for the continuously differentiable planar vector field. Uniqueness implies that its image over a minimal period is a simple closed curve, enclosing a region of positive area. Along the orbit, the differential form vanishes because and . Green's theorem, with positive orientation, therefore gives
a contradiction. This is the Bendixson-Dulac criterion in the whole plane; the fact that the enclosed region also lies in the domain is essential.
For the second-order equation set . The equivalent system is , . Its divergence is throughout the plane. Hence there are no nonconstant periodic solutions.
The nonconstant qualification is necessary: the equilibrium solutions , , do exist and are periodic in the literal sense of satisfying every positive period. The source's usual dynamical interpretation of “periodic solution” here is a nonconstant periodic orbit.

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