Chromium (web browser) by Ciro Santilli 40 Updated 2025-07-16
Google is trying to kill it as of 2021: www.omgubuntu.co.uk/2021/01/chromium-sync-google-api-removed The lack of sync is a major major blow. So selfish. Google makes billions, and it won't give in a little bit of settings storage...
activatedgeek/LeNet-5 by Ciro Santilli 40 Updated 2025-07-16
This repository contains a very clean minimal PyTorch implementation of LeNet-5 for MNIST.
It trains the LeNet-5 neural network on the MNIST dataset from scratch, and afterwards you can give it newly hand-written digits 0 to 9 and it will hopefully recognize the digit for you.
Ciro Santilli created a small fork of this repo at lenet adding better automation for:
Install on Ubuntu 24.10 with:
sudo apt install protobuf-compiler
git clone https://github.com/activatedgeek/LeNet-5
cd LeNet-5
git checkout 95b55a838f9d90536fd3b303cede12cf8b5da47f
virtualenv -p python3 .venv
. .venv/bin/activate
pip install \
  Pillow==6.2.0 \
  numpy==1.24.2 \
  onnx==1.13.1 \
  torch==2.0.0 \
  torchvision==0.15.1 \
  visdom==0.2.4 \
;
We use our own pip install because their requirements.txt uses >= instead of == making it random if things will work or not.
On Ubuntu 22.10 it was instead:
pip install
  Pillow==6.2.0 \
  numpy==1.26.4 \
  onnx==1.17.0 torch==2.6.0 \
  torchvision==0.21.0 \
  visdom==0.2.4 \
;
Then run with:
python run.py
This script:
  • does a fixed 15 epochs on the training data
  • it then uses the trained net from memory to check accuracy with the test data
  • then it also produces a lenet.onnx ONNX file which contains the trained network, nice!
It throws a billion exceptions because we didn't start the Visdom server, but everything works nevertheless, we just don't get a visualization of the training.
The terminal outputs lines such as:
Train - Epoch 1, Batch: 0, Loss: 2.311587
Train - Epoch 1, Batch: 10, Loss: 2.067062
Train - Epoch 1, Batch: 20, Loss: 0.959845
...
Train - Epoch 1, Batch: 230, Loss: 0.071796
Test Avg. Loss: 0.000112, Accuracy: 0.967500
...
Train - Epoch 15, Batch: 230, Loss: 0.010040
Test Avg. Loss: 0.000038, Accuracy: 0.989300
And the runtime on Ubuntu 22.10, P51 was:
real    2m10.262s
user    11m9.771s
sys     0m26.368s
One of the benefits of the ONNX output is that we can nicely visualize the neural network on Netron:
Figure 1.
Netron visualization of the activatedgeek/LeNet-5 ONNX output
. From this we can see the bifurcation on the computational graph as done in the code at:
output = self.c1(img)
x = self.c2_1(output)
output = self.c2_2(output)
output += x
output = self.c3(output)
This doesn't seem to conform to the original LeNet-5 however?
Optical microscope by Ciro Santilli 40 Updated 2025-07-16
Definition not very nice, as it excludes X-ray crystallography, which is also photon based.
Leeuwenhoek microscope by Ciro Santilli 40 Updated 2025-07-16
Figure 1. Source. This is a microscope, I kid you not. TODO photo of what you can see with it.
Video 1.
Two Photon Microscopy by Nemonic NeuroNex (2019)
Source. Shows a prototype of a two-photon electron microscope on an optical table, and describes it in good detail, well done.
X-ray crystallography by Ciro Santilli 40 Updated 2025-07-16
One of its main applications is to determine the 3D structure of proteins.
Sometimes you are not able to crystallize the proteins however, and the method cannot be used.
Crystallizing is not simple because:
  • you need a considerable amount of the protein
  • sometimes it only crystallizes if you add some extra small chemical that stabilizes it
Cryogenic electron microscopy can sometimes determine the structures of proteins that failed crystallization.
X-ray diffraction by Ciro Santilli 40 Updated 2025-07-16
Often used as a synonym for X-ray crystallography, or to refer more specifically to the diffraction part of the experiment (exluding therefore sample preparation and data processing).
As of 2022, this channel is still finding its feet. But it has promise.
Unfortunately it does not show sample preparation, and it does not use controlled cultures, so we are never sure which species are represented.
The channel is also notable for the fact that the author makes his own music.
Video 1.
Behind the Scenes by Sci-Inspi (2020)
Source. His name is Manuael, aka Manu, and he is the chemistry lab technician at a community college.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either https://OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact