Sandy Lerner is an American entrepreneur and venture capitalist, best known for her role as a co-founder of Cisco Systems, a leading technology company known for its networking hardware and software. Lerner played a significant part in the early development of Cisco, which was founded in 1984. In addition to her work at Cisco, she has been involved in various entrepreneurial and philanthropic endeavors. After leaving Cisco, Lerner focused on her interests in education and agribusiness.

KCNE2 is a gene that encodes a protein known as the potassium voltage-gated channel subfamily E member 2. This protein is part of the potassium ion channel family, which plays a critical role in the electrophysiological properties of cells, particularly in the heart and nervous system. KCNE2 functions as a regulatory subunit for specific K+ channels, influencing their conductivity and gating properties.

Channelopathies are a group of disorders caused by the dysfunction of ion channels, which are proteins that help regulate the flow of ions (such as sodium, potassium, calcium, and chloride) across cell membranes. These ion channels play critical roles in various physiological processes, including the generation and transmission of electrical signals in neurons and muscle cells, cardiac rhythm, and neurotransmitter release.

A diagonal is a line segment that connects two non-adjacent vertices of a polygon or polyhedron. In simpler terms, it is a line drawn from one corner (vertex) of a shape to another corner that is not next to it. For example: - In a **rectangle**, there are two diagonals that connect opposite corners. - In a **square**, the diagonals also connect opposite corners and are equal in length.

Yakov Rekhter is a prominent figure in the field of computer networking, particularly known for his contributions to the development of internet protocols. He is one of the original designers of the Border Gateway Protocol (BGP), which is a crucial protocol used to exchange routing information across the internet. BGP plays a vital role in making the internet a decentralized and scalable network.

Literary criticism is the analysis, interpretation, and evaluation of literary works. It encompasses a variety of approaches and methods used to understand texts, their meanings, and their effects on readers. Critics may examine elements such as themes, characters, style, structure, historical context, and cultural significance.

Literary theory is a field of study that seeks to understand, analyze, and interpret literature. It provides frameworks and approaches for examining texts and assists readers and critics in understanding the underlying principles and concepts that shape the creation and reception of literary works. Literary theory encompasses a wide range of methodologies and schools of thought, each with its own perspectives on the nature of literature, its functions, and its relationship to culture, society, and history.

The term "channelome" refers to the complete set of ion channels expressed in a particular cell, tissue, or organism. Ion channels are proteins that facilitate the movement of ions across cell membranes, played crucial roles in various physiological processes, including muscle contraction, neurotransmitter release, and maintaining the resting membrane potential of cells.

The geometry of complex numbers is a way to visually represent complex numbers using the two-dimensional Cartesian coordinate system, often referred to as the complex plane or Argand plane. In this representation, each complex number can be expressed in the form: \[ z = a + bi \] where \(a\) is the real part, \(b\) is the imaginary part, and \(i\) is the imaginary unit, defined as \(i^2 = -1\).

Acid-sensing ion channels (ASICs) are a group of ion channels that are primarily activated by acidic conditions (low pH) in the surrounding environment. They belong to the epithelial sodium channel/degenerin (ENaC/DEG) family of ion channels and play crucial roles in various physiological processes.

Return on Capital (ROC) is a financial metric used to assess a company's efficiency in generating profits from its capital. It measures how well a company utilizes its capital to generate earnings, providing insight into the effectiveness of its management and the attractiveness of its investment.

The Upside Potential Ratio (UPR) is a financial metric used to assess the performance of an investment relative to its potential for capital appreciation. It measures the amount a security (or portfolio) could gain in value relative to the losses it might incur during downturns. The ratio provides insight into the risk-reward profile of an investment.

HTR3A (5-hydroxytryptamine receptor 3A) is a gene that encodes a subunit of the 5-HT3 receptor, which is a type of neurotransmitter receptor that responds to the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT).

HTR3B, or 5-hydroxytryptamine receptor 3B, is a gene that encodes a protein which is part of the serotonin receptor family. Specifically, it is one of the subunits of the 5-HT3 receptor, a type of ligand-gated ion channel that is activated by the neurotransmitter serotonin (5-HT).

HTR3C refers to the serotonin receptor 3C, which is a subtype of the 5-HT3 receptor family. These receptors are ligand-gated ion channels that are activated by the neurotransmitter serotonin (5-HT). The 5-HT3 receptors are primarily involved in the central and peripheral nervous systems, playing crucial roles in processes such as mood regulation, anxiety, nausea, and vomiting.

Proton channels are specialized protein structures that facilitate the selective movement of protons (H⁺ ions) across cell membranes. These channels play crucial roles in various physiological processes, including cellular respiration, signal transduction, and maintaining pH balance within cells.

The 5-HT3 receptor is a type of serotonin receptor that is part of the ligand-gated ion channel family. It is primarily involved in mediating the effects of serotonin (5-hydroxytryptamine, or 5-HT) in the central and peripheral nervous systems.

CLIC5 (Chloride Intracellular Channel 5) is a protein that is part of the CLIC (Chloride Intracellular Channel) family. These proteins are known for their role in cellular chloride ion transport and signaling. CLIC5, in particular, has been implicated in various physiological processes, including cell volume regulation, muscle contraction, and potentially playing a role in certain diseases.

The calcium channel, voltage-dependent, T type, alpha 1H subunit, commonly referred to as **CACNA1H**, is a protein that forms part of a type of calcium channel in the body. Specifically, it is a subunit of the T-type calcium channels, which are involved in various physiological processes.