We can almost reach the Lie algebra of any isometry group in a single go. For every in the Lie algebra we must have:
because has to be in the isometry group by definition as shown at Section "Lie algebra of a matrix Lie group".
Then:
so we reach:
With this relation, we can easily determine the Lie algebra of common isometries:
When viewed as matrices, it is the group of all matrices that preserve the dot product, i.e.:
This implies that it also preserves important geometric notions such as norm (intuitively: distance between two points) and angles.
This is perhaps the best "default definition".
Transistor by Ciro Santilli 40 Updated 2025-07-16
Although transistors were revolutionary, it is fun to note that they were just "way cheaper and more reliable and smaller" versions of exactly the main functions that a vacuum tube could achieve
The orthogonal group has 2 connected components:
It is instructive to visualize how the looks like in :
  • you take the first basis vector and move it to any other. You have therefore two angular parameters.
  • you take the second one, and move it to be orthogonal to the first new vector. (you can choose a circle around the first new vector, and so you have another angular parameter.
  • at last, for the last one, there are only two choices that are orthogonal to both previous ones, one in each direction. It is this directio, relative to the others, that determines the "has a reflection or not" thing
As a result it is isomorphic to the direct product of the special orthogonal group by the cyclic group of order 2:
A low dimensional example:
because you can only do two things: to flip or not to flip the line around zero.
Note that having the determinant plus or minus 1 is not a definition: there are non-orthogonal groups with determinant plus or minus 1. This is just a property. E.g.:
has determinant 1, but:
so is not orthogonal.
Whole cell simulation by Ciro Santilli 40 Updated 2025-07-16
Ciro Santilli started taking some notes at: github.com/cirosantilli/awesome-whole-cell-simulation. but they are going to be all migrated here.
It is interesting to note how one talks about single cell analysis, in contrast to whole cell simulation: experimentally it is hard to analyse a single cell. But theoretically, it is hard to simulate a single cell. This mismatch is perhaps the ultimate frontier of molecular biology.
Video 1.
A Computational Whole-Cell Model Predicts Genotype From Phenotype by Markus Covert (2013)
Source.
Based on the , and derived at Lie algebra of we can calculate the Lie bracket as:
Haascope by Ciro Santilli 40 Updated 2025-07-16
By Andy Haas, an experimental particle physics professor: as.nyu.edu/content/nyu-as/as/faculty/andy-haas.html What an awesome dude!
Video 1.
Haasoscope prototype, 2 4-channel boards
. Source.

Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either https://OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact