The mandatory xkcd: xkcd 927: Standards.

Some anecdotes.

Ciro Santilli never splits up functions unless there is more than one calling point. If you split early, the chances that the interface will be wrong are huge, and a much larger refactoring follows.

If you just want to separate variables, just use a scope e.g.:

int cross_block_var;

// First step.
{
    int myvar;
}

// Second step.
{
    int myvar;
}

Ciro has seen and had to deal with in his lifetime with two projects that had like 3 to 10 git separate Git repositories, all created and maintained by the same small group of developers of the same organization, even though one could not build without the other. Keeping everything in sync was Hell! Why not just have three directories inside a single repository with a single source of truth?

Another important case: Linux should have at least a C standard library, init system, and shell in-tree, like BSD Operating Systems, as mentioned at: Section "Linux".

Sometimes you are really certain that something is a required substep for another thing that is coming right afterwards.

When things are this concrete, fine, just do the substep.

But you have to always beware of cases where "I'm sure this will be needed at some unspecified point in the future", because such points tends to never happen.

YAGNI is so fundamental, there are several closely related concepts to it:

20 minutes in optimal conditions, with a crazy multiple start sites mechanism: E. Coli starts DNA replication before the previous one finished.

Otherwise, naively, would take 60-90 minutes just to replicate and segregate the full DNA otherwise. So it starts copying multiple times.

Ciro Santilli would like to fully understand the statements and motivations of each the problems!

Easy to understand the motivation:

Hard to understand the motivation!

Working remotely is hard if you don't already highly master the software and enterprise systems used.

Also you don't feel people's love as strongly, and usefulness is built on love, see also Steve Jobs's Pixar office space design philosophy.

But please, give workers a small silent office so that we can concentrate instead of a silly open space, and create an internal social network so people can see what others are doing.

Remote working is much better if the majority of the team also does it, otherwise you will get excluded. Maybe after VR...

Bought May 2024 to be my clean crypto-only computer. Searched for cheapest 1 TB disk 16 GB RAM not too old on Amazon with Ubuntu certification, and that was it at £479.00.

Some reviews:

OPSEC: will run only cryptocurrency wallets and nothing else. Will connect to Internet, but never ever to a non clean USB flash drive.

The OPSEC for this machine supposes:

Bootstrap OPSEC:It must have taken about one week running full time to sync the Monero blockchain which at the time was at about 3.1M blocks! I checked on system explorer, and CPU and internet usage was never maxed out, suggesting simply slow network. But the computer still overheated quite a bit and froze a few times.

Huge interest overlap with Ciro Santilli, e.g. he's into

github.com/CovertLab/WholeCellEcoliRelease is a whole cell simulation model created by Covert Lab and other collaborators.

The project is written in Python, hurray!

But according to te README, it seems to be the use a code drop model with on-request access to master. Ciro Santilli asked at rationale on GitHub discussion, and they confirmed as expected that it is to:

The project is a followup to the earlier M. genitalium whole cell model by Covert lab which modelled Mycoplasma genitalium. E. Coli has 8x more genes (500 vs 4k), but it the undisputed bacterial model organism and as such has been studied much more thoroughly. It also reproduces faster than Mycoplasma (20 minutes vs a few hours), which is a huge advantages for validation/exploratory experiments.

The project has a partial dependency on the proprietary optimization software CPLEX which is freeware, for students, not sure what it is used for exactly, from the comment in the requirements.txt the dependency is only partial.

This project makes Ciro Santilli think of the E. Coli as an optimization problem. Given such external nutrient/temperature condition, which DNA sequence makes the cell grow the fastest? Balancing metabolites feels like designing a Factorio speedrun.

There is one major thing missing thing in the current model: promoters/transcription factor interactions are not modelled due to lack/low quality of experimental data: github.com/CovertLab/WholeCellEcoliRelease/issues/21. They just have a magic direct "transcription factor to gene" relationship, encoded at reconstruction/ecoli/flat/foldChanges.tsv in terms of type "if this is present, such protein is expressed 10x more". Transcription units are not implemented at all it appears.

Everything in this section refers to version 7e4cc9e57de76752df0f4e32eca95fb653ea64e4, the code drop from November 2020, and was tested on Ubuntu 21.04 with a docker install of docker.pkg.github.com/covertlab/wholecellecolirelease/wcm-full with image id 502c3e604265, unless otherwise noted.

This is a term "invented" by Ciro Santilli to refer to quantum compilers that are able to convert non-specifically-quantum (functional, since there is no state in quantum software) programs into quantum circuit.

The term is made by adding "quantum" to the more "classical" concept of "high-level synthesis", which refers to software that converts an imperative program into register transfer level hardware, typicially for FPGA applications.

101 Crawfords Corner Rd Holmdel, NJ 07733 USA

It started with radio research apparently, including Karl Guthe Jansky.

They had a smaller building first: youtu.be/BPq_ZyOvbsg?t=51 and in 1962 opened the large new building.