Ciro Santilli @cirosantilli 37

BLAST is a sequence alignment.

The NCBI free-to-use BLAST server: blast.ncbi.nlm.nih.gov/Blast.cgi. Having a centralized query server is fundamental, because the gain of sequence alignment really comes from having one huge database to link information together, which is best centralized.

Low budget.

Things that can be understood are boring.

Aaron Swartz agrees: www.aaronsw.com/weblog/looperexplained "Next week we'll explain Primer." He never did though :'-(

The premise that "we can't make AGI, but we know enough about the human brain to upload on to a computer" is flawed. Edit: after reading Superintelligence by Nick Bostrom (2014), Ciro Santilli was convinced otherwise. What is flawed is of course just the "extracting connectome with macroscopic probes part". A post mortem connectome extraction with microtome is much more believable. But of course they weren't going to show fake slices of Jonny Depp's brain, are they? Famous actor bodies are sacred! What a huge lost opportunity. On the other hand however, the scale of the first connectome extraction would be arguably too huge to be undertaken by a random pair of rogue researchers. The same would also likely apply to any first time human brain connectome. It would much more likely be a huge public effort, much like the Human Genome Project.

But this film does have the merit of exploring how an AGI might act to take over the AGI might act to take over the world once created, notably by creating its own physical research laboratory. Though it doesn't feel likely that it could go under the radar for 2 years given the energetic requirements of the research. Even the terrorists find it before the FBI!

I also wish they had shown the dildo (or more likely, direct stimulation!) computerized Jonny Depp used to use with his wife before he managed to re-synthesized his body. But you know, 18+ would cut too much profits. Ah, what a shame.

IMDb: www.imdb.com/title/tt0066839/

Episodes of the life of Blaise Pascal.

visualizing the Riemann hypothesis and analytic continuation by 3Blue1Brown (2016) is a good quick visual non-mathematical introduction is to it.

One of the Millennium Prize Problems and Hilbert's problems.

In the past, most computer designers would have their own fabs.

But once designs started getting very complicated, it started to make sense to separate concerns between designers and fabs.

What this means is that design companies would primarily write register transfer level, then use electronic design automation tools to get a final manufacturable chip, and then send that to the fab.

It is in this point of time that TSMC came along, and benefied and helped establish this trend.

The term "Fabless" could in theory refer to other areas of industry besides the semiconductor industry, but it is mostly used in that context.

Reaches 2 mK^[ref]. youtu.be/upw9nkjawdy?t=487 from Video "Building a quantum computer with superconducting qubits by Daniel Sank (2019)" mentions that 15 mK are widely available.

Used for example in some times of quantum computers, notably superconducting quantum computers. As mentioned at: youtu.be/uPw9nkJAwDY?t=487, in that case we need to go so low to reduce thermal noise.

The half-life of radioactive decay, which as discovered a few years before quantum mechanics was discovered and matured, was a major mystery. Why do some nuclei fission in apparently random fashion, while others don't? How is the state of different nuclei different from one another? This is mentioned in Inward Bound by Abraham Pais (1988) Chapter 6.e Why a half-life?

The term also sees use in other areas, notably biology, where e.g. RNAs spontaneously decay as part of the cell's control system, see e.g. mentions in E. Coli Whole Cell Model by Covert Lab.

The mantra of the computer simulation engineer.

100 10-20 minute videos properly split by topic, good resource!

Instructor: Barton Zwiebach.

Free material from university courses:

TODO what's the largest molecule done on a classical computer?

In the context of quantum computing of the 2020's, a "classical computer" is a computer that is not "quantum", i.e., the then dominating CMOS computers.