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General paresis, tabes dorsalis and diagnostic framework; not a description of what was proved in 1864.
Recommendations §§1.4.1–1.4.2 distinguish initial stabilization from assessment and require exclusion of important traumatic brain injury before attributing impaired consciousness to intoxication. Indexed official text was available; direct retrieval intermittently returned HTTP 403.
Neuronal excitability is a neuron's capacity to produce regenerative electrical responses to input. In a spiking neuron, sufficiently strong input recruits voltage-gated ion channels and initiates an action potential; the threshold and firing pattern depend on the membrane potential, recent activity and the available ion channels.
In current clamp, a series of input electric current steps can reveal the smallest tested stimulus that elicits an action potential and how firing changes with stronger input. These measurements distinguish a neuron that receives large inputs from one whose own membrane converts modest inputs into repeated spikes.[ref]
Multiple Two-Photon Targeted Whole-Cell Patch-Clamp Recordings From Monosynaptically Connected Neurons in vivo by Jean-Sébastien Jouhanneau and others. Current-step characterization described in the recording protocol
Epilepsy is a brain disorder involving an enduring predisposition to epileptic seizures. The condition includes different seizure types and causes; a single seizure provoked by a temporary disturbance does not automatically establish it.
The distinction between an individual event and a continuing predisposition is important in both diagnosis and research. Counting events, classifying their mechanism and investigating the underlying cause answer different questions.[ref]
A practical clinical definition of epilepsy by Robert S. Fisher and others. Summary and conceptual definition
A seizure is a transient episode of altered function. In neurological usage, an epileptic seizure arises from abnormal excessive or synchronized neural activity; episodes resembling seizures can also have other mechanisms.
A profound sustained impairment of consciousness in which a person cannot be awakened. This medical use is distinct from coma.
Alcohol withdrawal is a syndrome arising after a reduction or cessation of sustained alcohol exposure in a physiologically adapted person. Symptoms reflect altered regulation of neural activity and can range from tremor and autonomic activation to seizures or delirium tremens.
Alcohol withdrawal is distinct from current alcohol intoxication. The timing of exposure and its reduction matters when interpreting apparently similar changes in behavior or awareness.[ref]
Substance use and mental health by the National Institute of Mental Health. Tolerance and withdrawal in substance-use disorders
Polyneuropathy is dysfunction affecting multiple peripheral nerves. It can involve sensory, motor or autonomic fibers, with patterns that depend on the affected cell components and the distribution of injury.
A length-dependent pattern often begins distally because long axons are especially vulnerable to some systemic processes. This is a different anatomical organization from a single compressed nerve or a lesion confined to the spinal cord.
A tendon reflex is a muscle response elicited by a brief stretch, commonly produced by tapping its tendon. Stretch activates sensory input to a spinal circuit that can excite the corresponding motor neurons.
Apparent inability to move without necessarily having motor denervation; pain from osteochondritis or periostitis in congenital syphilis is one example.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





