RNA immunoprecipitation followed by sequencing of recovered RNA. Enrichment suggests association with the selected protein complex under the assay conditions, not necessarily direct binding to every recovered transcript.

A member of a neural RNA-binding protein family with position-dependent effects on alternative splicing. Binding-site position helps predict activation or repression of exon inclusion.^[ref]

A member of a family of sequence-selective RNA-binding proteins involved in regulating alternative splicing.

Sequence-selective binding near an alternative exon can change recruitment or activity of the splicing machinery. The same binding motif can be associated with different outcomes depending on position and the surrounding regulatory context. ^[ref]

A polypyrimidine-tract-binding RNA-binding protein family member involved in precursor-RNA processing and other aspects of gene expression.

A heterogeneous nuclear ribonucleoprotein involved in RNA processing. Its binding can respond to modification-dependent accessibility of an RNA motif.^[ref]

A protein family that binds small guide RNAs and participates in sequence-directed regulation. Guide complementarity can identify targets, but cleavage activity varies among family members and pathways.

A protein that binds a poly(A) tail and can influence messenger RNA stability and biological translation.

An insulin-like growth factor 2 messenger RNA-binding protein family member. Stabilization and enhanced biological translation of modified targets have been reported; this does not identify every modification-dependent stabilizer as an IGF2BP protein.^[ref]

Zipcode-binding protein 1, also known as IGF2BP1. It recognizes a localization element in beta-actin messenger RNA and can repress its biological translation during transport.^[ref]

A member of a repeat-containing protein family with major roles in organellar RNA recognition and regulation. Different members can support distinct processing, editing, stability or translational functions.

A bacteriophage protein recognizing a defined RNA hairpin, used as a fusion partner in RNA tethering assays and RNA imaging. Hairpin arrays and bound fusion proteins can themselves perturb RNA behaviour.

A bacteriophage RNA-recognition module used as a complement to MS2 coat protein for experimental RNA recruitment and imaging.

A family of microRNA-silencing effectors linking Argonaute-associated recognition to downstream repression and RNA-deadenylation machinery.^[ref]

A budding-yeast regulator that targets selected AU-rich transcripts for degradation during iron deficiency, reallocating resources away from iron-consuming processes.^[ref]

A common structured RNA-binding domain. Multiple motifs in a protein can recognize separated RNA segments and support geometry-dependent regulation.

A Drosophila regulator whose RNA recognition supports sex-specific and autoregulatory splicing. It can act through competition at early recognition or through substrate-specific later spliceosomal interactions.

An RNA-associated regulator of stress-granule assembly. Requirements for assembly depend on stress and partner context.

Like G3BP2, it can organize interactions among RNA and proteins during stress-granule formation. Perturbing those interactions distinguishes a direct assembly requirement from mere co-localization in an already formed granule. ^[ref]

G3BP2 is an RNA-binding protein involved in the organization of stress granules. Together with related components, it helps couple RNA-protein interactions to formation of a condensed cytoplasmic assembly. The granule state depends on concentration, binding partners and stress context. Presence of G3BP2 in a granule supports participation, while testing a requirement for assembly needs depletion or a defined functional perturbation. ^[ref]

An RNA-binding protein that collaborates with Nanos and other factors in sequence-specific repression of target messenger RNAs.