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Recognition and positioning of a primary hairpin help the Drosha complex generate a shorter precursor. Later export and Dicer processing are additional stages, so loss of a mature microRNA can arise from defects at several different steps. [ref]
NCBI Gene by the National Library of Medicine. Homo sapiens, DGCR8 record, Summary: primary microRNA processing
Profiling of preserved ribosomal and small-subunit-associated complexes to distinguish stages including scanning and recycling. Captured distributions remain subject to crosslinking and fragment-selection biases.
An RNA fragment protected from digestion by a ribosome in the assayed preparation. Length, genomic position and frame periodicity help distinguish productive biological translation from other protected RNA.
Frame-related enrichment at a three-base interval in correctly positioned translating-ribosome reads. It supports biological translation but is difficult to establish for very short or low-count reading frames.
Methods that preferentially capture ribosomes near biological translation starts, often using short inhibitor treatments. Candidate peaks require calibration and independent validation.
One of the major assemblies forming a ribosome. Small-subunit scanning and reinitiation can persist after release of the large subunit at a short upstream open reading frame.
A bacterial factor that assists peptide-bond formation at susceptible sequences, including consecutive prolines. Functional maturation of the factor and substrate sequence affect its activity.[ref]
An enzyme that processes appropriate double-stranded RNA substrates into small guide-RNA precursors in several RNA interference pathways.
An ideal flow model in which all fluid elements have the same transit time. For first-order radioactive decay the outlet-to-inlet radioactive activity concentration ratio is .
A continuous reactor with uniform contents. At steady state for first-order radioactive decay, ; young material can leave before the mean residence time.
The spinor boost changes the component-magnitude ratio by . The associated active positive- Lorentz boost therefore changes the polar half-angle as displayed and leaves azimuth unchanged. Its null-vector time scale changes by , which must be retained separately when normalizing a spinor to encode direction.
For two coincident observers with relative motion along the sightline to a small distant source, its angular diameter changes by a rapidity factor. A boost toward the source compresses its incoming angular cone: for angular radius . For a small source the larger-to-smaller diameter ratio is , giving the displayed relative speed. A finite angular size requires the half-angle formula, and arbitrary transverse relative motion cannot be inferred from one diameter ratio alone.
Pinned article: Introduction to the OurBigBook Project
Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Intro to OurBigBook
. Source. We have two killer features:
- topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculusArticles of different users are sorted by upvote within each article page. This feature is a bit like:
- a Wikipedia where each user can have their own version of each article
- a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.Figure 1. Screenshot of the "Derivative" topic page. View it live at: ourbigbook.com/go/topic/derivativeVideo 2. OurBigBook Web topics demo. Source. - local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
- to OurBigBook.com to get awesome multi-user features like topics and likes
- as HTML files to a static website, which you can host yourself for free on many external providers like GitHub Pages, and remain in full control
Figure 2. You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website.Figure 3. Visual Studio Code extension installation.Figure 5. . You can also edit articles on the Web editor without installing anything locally. Video 3. Edit locally and publish demo. Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension. - Infinitely deep tables of contents:
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact





