A protein family that binds small guide RNAs and participates in sequence-directed regulation. Guide complementarity can identify targets, but cleavage activity varies among family members and pathways.
A germline nuclear Caenorhabditis elegans Argonaute required for maintenance of some inherited small-RNA-dependent silencing states.
Endonucleolytic target cleavage directed by a small-RNA guide and a catalytically competent Argonaute. Cleavage typically falls opposite guide positions 10 and 11; not all Argonautes can slice.
An Argonaute-family branch binding piRNAs. Cytoplasmic cleavage and nuclear transcriptional silencing protect the germline in many animals, with important species and tissue differences.
The Caenorhabditis elegans Piwi-family protein associated with 21U piRNAs and germline surveillance of RNA expression.
A mouse Piwi-family protein associated with fetal male germ-cell transposon repression and de novo DNA methylation.
A mouse Piwi-family protein participating in germ-cell piRNA biogenesis and transposon control.
A Drosophila Piwi-family protein that participates with Aubergine in piRNA ping-pong amplification.
A Drosophila Piwi-family protein participating in germline piRNA-mediated regulation, including ping-pong amplification.
An Argonaute protein participating in RNA-directed chromatin silencing.

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